Cytokine profiles and their roles in development of provoked vulvodynia.

Autor: Le D; School of Medicine, Texas Tech University Health Sciences Center Permian Basin, Odessa, TX, USA., Le T; School of Medicine, Texas Tech University Health Sciences Center Permian Basin, Odessa, TX, USA., Sanchez A; School of Medicine, Texas Tech University Health Sciences Center Permian Basin, Odessa, TX, USA., Gandhi K; School of Medicine, Texas Tech University Health Sciences Center Permian Basin, Odessa, TX, USA., Garza J; School of Medicine, Texas Tech University Health Sciences Center Permian Basin, Odessa, TX, USA., Gibson A; School of Medicine, Texas Tech University Health Sciences Center Permian Basin, Odessa, TX, USA., Galloway M; School of Medicine, Texas Tech University Health Sciences Center Permian Basin, Odessa, TX, USA. Electronic address: Michael.Galloway@ttuhsc.edu., Ventolini G; School of Medicine, Texas Tech University Health Sciences Center Permian Basin, Odessa, TX, USA.
Jazyk: angličtina
Zdroj: Journal of reproductive immunology [J Reprod Immunol] 2024 Sep; Vol. 165, pp. 104313. Date of Electronic Publication: 2024 Aug 03.
DOI: 10.1016/j.jri.2024.104313
Abstrakt: Provoked, localized, vulvodynia (PVD) is the main subtype of vulvodynia. Although the etiology of PVD is still a topic of debate, inflammation caused by cytokines responding to a dysregulated microbiome is one of the leading proposed theories. Therefore, the purpose of our study is to further explore the cytokine profiles in the study group with PVD using multiplex immunoassays based on electrochemiluminescence. We compared a panel of 26 distinct cytokines levels in the study group with PVD (n = 23) to the control group (n = 18) and cytokine concentrations were measured using MESO QuickPlex SQ 120 instrument with 5 different multiplex assays. Statistical analysis used the Mann-Whitney U test, two-sided p-values, and a significance level of α = 0.05. Differences in cytokine concentrations are described as negligible, small, medium, or large based on Cliff's δ. Concentrations of three cytokines were significantly lower in the PVD group: a large difference in IP-10 (p = 0.029*) and medium differences in IL-1RA 4 (p = 0.030*) and IL-12 (p = 0.034*). One cytokine level was significantly higher in the PVD group: a medium difference for IL-6 (p = 0.037*). Due to the lack of consistency in elevation of inflammatory profiles, it is not enough to support persistent inflammation as the etiology behind PVD. However, these findings may indicate there is a possible immune response deficiency in some patients who have PVD. The resemblance of cytokine profile in our study to cytokine profile of people with chronic yeast infection further support this proposed mechanism behind PVD. Future studies involving history and testing for yeast infection are necessary to explore this possibility further.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper
(Published by Elsevier B.V.)
Databáze: MEDLINE
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