Repair of genomic interstrand crosslinks.

Autor: Bellani MA; Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA., Shaik A; Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA., Majumdar I; Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA., Ling C; Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA., Seidman MM; Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA. Electronic address: seidmanm@grc.nia.nih.gov.
Jazyk: angličtina
Zdroj: DNA repair [DNA Repair (Amst)] 2024 Sep; Vol. 141, pp. 103739. Date of Electronic Publication: 2024 Jul 30.
DOI: 10.1016/j.dnarep.2024.103739
Abstrakt: Genomic interstrand crosslinks (ICLs) are formed by reactive species generated during normal cellular metabolism, produced by the microbiome, and employed in cancer chemotherapy. While there are multiple options for replication dependent and independent ICL repair, the crucial step for each is unhooking one DNA strand from the other. Much of our insight into mechanisms of unhooking comes from powerful model systems based on plasmids with defined ICLs introduced into cells or cell free extracts. Here we describe the properties of exogenous and endogenous ICL forming compounds and provide an historical perspective on early work on ICL repair. We discuss the modes of unhooking elucidated in the model systems, the concordance or lack thereof in drug resistant tumors, and the evolving view of DNA adducts, including ICLs, formed by metabolic aldehydes.
Competing Interests: Declaration of Competing Interest The authors declare no competing interests.
(Published by Elsevier B.V.)
Databáze: MEDLINE
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