Piezoelectric biomaterials with embedded ionic liquids for improved orthopedic interfaces through osseointegration and antibacterial dual characteristics.

Autor: Carvalho EO; Physics Centre of Minho and Porto Universities (CF-UM-UP), LaPMET - Laboratory of Physics for Materials and Emergent Technologies, University of Minho, 4710-057 Braga, Portugal; IB-S - Institute for Research and Innovation on Bio-Sustainability, University of Minho, 4710-057 Braga, Portugal., Marques-Almeida T; Physics Centre of Minho and Porto Universities (CF-UM-UP), LaPMET - Laboratory of Physics for Materials and Emergent Technologies, University of Minho, 4710-057 Braga, Portugal; IB-S - Institute for Research and Innovation on Bio-Sustainability, University of Minho, 4710-057 Braga, Portugal., Cruz BDD; Physics Centre of Minho and Porto Universities (CF-UM-UP), LaPMET - Laboratory of Physics for Materials and Emergent Technologies, University of Minho, 4710-057 Braga, Portugal; Centre of Chemistry, University of Minho, Braga 4710-057, Portugal; Centre of Molecular and Environmental Biology, University of Minho, 4710-057 Braga, Portugal., Correia DM; Centre of Chemistry, University of Minho, Braga 4710-057, Portugal., Esperança JMSS; LAQV/REQUIMTE, Department of Chemistry, NOVA School of Science and Technology, FCT NOVA, 2829-516 Caparica, Portugal., Irastorza I; Physics Centre of Minho and Porto Universities (CF-UM-UP), LaPMET - Laboratory of Physics for Materials and Emergent Technologies, University of Minho, 4710-057 Braga, Portugal; BCMaterials, Basque Center Centre for Materials, Applications, and Nanostructures, UPV/EHU Science Park, 48940 Leioa, Spain., Silvan U; BCMaterials, Basque Center Centre for Materials, Applications, and Nanostructures, UPV/EHU Science Park, 48940 Leioa, Spain; Ikerbasque, Basque Foundation for Science, 48009 Bilbao, Spain., Fernandes MM; Physics Centre of Minho and Porto Universities (CF-UM-UP), LaPMET - Laboratory of Physics for Materials and Emergent Technologies, University of Minho, 4710-057 Braga, Portugal; Centre for MicroElectroMechanics Systems (CMEMS), University of Minho, 4710-057 Guimarães, Portugal; LABBELS-Associate Laboratory, Braga, Guimarães, Portugal., Lanceros-Mendez S; Physics Centre of Minho and Porto Universities (CF-UM-UP), LaPMET - Laboratory of Physics for Materials and Emergent Technologies, University of Minho, 4710-057 Braga, Portugal; BCMaterials, Basque Center Centre for Materials, Applications, and Nanostructures, UPV/EHU Science Park, 48940 Leioa, Spain; Ikerbasque, Basque Foundation for Science, 48009 Bilbao, Spain. Electronic address: senentxu.lanceros@bcmaterials.net., Ribeiro C; Physics Centre of Minho and Porto Universities (CF-UM-UP), LaPMET - Laboratory of Physics for Materials and Emergent Technologies, University of Minho, 4710-057 Braga, Portugal; IB-S - Institute for Research and Innovation on Bio-Sustainability, University of Minho, 4710-057 Braga, Portugal. Electronic address: cribeiro@fisica.uminho.pt.
Jazyk: angličtina
Zdroj: Biomaterials advances [Biomater Adv] 2024 Nov; Vol. 164, pp. 213970. Date of Electronic Publication: 2024 Jul 27.
DOI: 10.1016/j.bioadv.2024.213970
Abstrakt: Orthopedic implant failures, primarily attributed to aseptic loosening and implant site infections, pose significant challenges to patient recovery and lead to revision surgeries. Combining piezoelectric materials with ionic liquids as interfaces for orthopedic implants presents an innovative approach to addressing both issues simultaneously. In this study, films of poly(vinylidene fluoride-trifluoroethylene) (P(VDF-TrFE)) incorporated with 1-ethyl-3-methylimidazolium hydrogen sulfate ([Emim][HSO 4 ]) ionic liquid were developed. These films exhibited strong antibacterial properties, effectively reducing biofilm formation, thereby addressing implant-related infections. Furthermore, stem cell-based differentiation assays exposed the potential of the composite materials to induce osteogenesis. Interestingly, our findings also revealed the upregulation of calcium channel expression as a result of electromechanical stimulation, pointing to a mechanistic basis for the observed biological effects. This work highlights the potential of piezoelectric materials with ionic liquids to improve the longevity and biocompatibility of orthopedic implants. Offering dual-functionality for infection prevention and bone integration, these advancements hold significant potential for advancing orthopedic implant technologies and improving patient outcomes.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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