Zinc abates sodium benzoate -induced testicular dysfunction via upregulation of Nrf2/ HO-1/ Nf-κB signaling and androgen receptor gene.

Autor: Ajibare AJ; Department of Physiology, College of Medicine, Lead City University, Ibadan, Oyo-State, Nigeria., Odetayo AF; Department of Physiology, Faculty of Basic Medical Sciences, Federal University of Health Sciences, Ila Orangun, Nigeria. Electronic address: adeyemiodetayo@gmail.com., Akintoye OO; Department of Physiology, College of Medicine, Lead City University, Ibadan, Oyo-State, Nigeria; Department of Physiology, College of Medicine, Ekiti State University, Ado-Ekiti, Ekiti State, Nigeria., Oladotun AJ; Hospital Management Board, Ekiti State, Nigeria., Hamed MA; Department of Medical Laboratory Science, Afe Babalola University, Ado-Ekiti, Nigeria; The Brainwill Laboratories and Biomedical Services, Osogbo, Nigeria.
Jazyk: angličtina
Zdroj: Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) [J Trace Elem Med Biol] 2024 Dec; Vol. 86, pp. 127505. Date of Electronic Publication: 2024 Jul 26.
DOI: 10.1016/j.jtemb.2024.127505
Abstrakt: Background: Sodium Benzoate (SB) is used in daily products such as drinks, juices, sauces, oils, ketchup, toothpaste, mouthwashes, cosmetics, dentifrices, and pharmaceutical products. However, SB has been implicated in gonadotoxicity even at a dosage within the safe limit. Zinc (Zn), on the other hand, has been shown to improve various fertility indices. Hence, this study was designed to explore the possible ameliorative effect of Zn on SB-induced testicular toxicity.
Methods: Animals were randomly divided into control, SB, Zn, and SB+Zn. All treatment lasted for 28 days.
Results: SB treatment caused a derangement in reproductive hormone levels, sperm function, and kinematics and a down-regulation of the Androgen receptor (ANDR). Also, a decrease in testicular levels of SOD, CAT, GSH, Nrf2, and HO- 1 activity and an increase in IL-1β, TNF-α, Nf-κB, and Caspase 3 were observed. These SB-induced distortions were ameliorated in SB-treated rats exposed to Zn.
Conclusion: Our study suggests that zinc abates SB-induced testicular toxicity by modulating Nrf2/HO-1/ Nf-κB signaling and ANDR upregulation.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier GmbH. All rights reserved.)
Databáze: MEDLINE
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