Adverse pregnancy outcomes associated with endometriosis in Ukraine: results a multicenter study.

Autor:	Salmanov AG; SHUPYK NATIONAL HEALTHCARE UNIVERSITY OF UKRAINE, KYIV, UKRAINE; INSTITUTE OF PEDIATRICS, OBSTETRICS AND GYNECOLOGY OF THE NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE, KYIV, UKRAINE., Artyomenko VV; ODESA NATIONAL MEDICAL UNIVERSITY, ODESA, UKRAINE., Shchedrov AO; SCHOOL OF MEDICINE OF V. N. KARAZIN KHARKIV NATIONAL UNIVERSITY, KHARKIV, UKRAINE., Prishchepa AP; KYIV CITY MATERNITY HOSPITAL NO3, KYIV, UKRAINE., Korniyenko SM; ODESA NATIONAL MEDICAL UNIVERSITY, ODESA, UKRAINE., Chubatyy AI; BOGOMOLETS NATIONAL MEDICAL UNIVERSITY, KYIV, UKRAINE., Maidannyk IV; BOGOMOLETS NATIONAL MEDICAL UNIVERSITY, KYIV, UKRAINE., Chorna OO; BOGOMOLETS NATIONAL MEDICAL UNIVERSITY, KYIV, UKRAINE., Rud VO; NATIONAL PIROGOV MEMORIAL MEDICAL UNIVERSITY, VINNYTSIA, UKRAINE., Strakhovetskyi VS; MEDICAL CENTRE 'ASHERA', KHARKIV, UKRAINE., Knyhin MV; MEDICAL CENTRE 'ASHERA', KHARKIV, UKRAINE., Padchenko AS; KYIV PERINATAL CENTER, KYIV, UKRAINE.
Jazyk:	angličtina
Zdroj:	Wiadomosci lekarskie (Warsaw, Poland : 1960) [Wiad Lek] 2024; Vol. 77 (6), pp. 1113-1121.
DOI:	10.36740/WLek202406101
Abstrakt:	Objective: Aim: To estimate pregnancy outcomes associated with endometriosis in Ukraine. Patients and Methods: Materials and Methods: We performed the multicentre prospective cohort study during the period from January 1st, 2019 to December 31st, 2021. The study included pregnant women aged ≥18 years hospitalized in 17 hospitals from 15 regions of Ukraine. Logistic regression analysis provided odds ratios (OR) with 95% confidence intervals (CI). Results: Results: Of the 27,558 women, 990 (3,6%) reported a diagnosis of endometriosis before pregnancy. In 990 deliveries, women with endometriosis had a higher risk of hypertension in pregnancy (OR 1.2, 95% CI 1.0-1.3), preeclampsia (OR 1.4, 95% CI 1.3-1.5), severe preeclampsia (OR 1.7, 95% CI 1.5-2.3), hemorrhage in pregnancy (OR 2.3, 95% CI 2.0-2.5), placental abruption (OR 2.0, 95% CI 1.7-2.3), placenta previa (OR 3.9, 95% CI 3.5-4.3), premature rupture of membranes (OR 1.7, 95% CI 1.5-1.8), and retained placenta (OR 3.1, 95% CI 1.4-6.6). The neonates had increased risks of preterm birth before 28 weeks (OR 3.1, 95% CI 2.7-3.6), birth before 34 weeks (OR 3.2, 95% CI 2.8-3.6), being small for gestational age (OR 1.5, 95% CI 1.4-1.6), being diagnosed with congenital malformations (OR 1.3, 95% CI 1.3-1.4), and neonatal death (OR 1.8, 95% CI 1.4-2.1). Conclusion: Conclusions: Pregnant women with endometriosis are at elevated risk for serious and important adverse maternal, fetal and neonatal outcomes. The magnitude of these complications calls for more intensive antenatal care of pregnant women with endometriosis.
Databáze:	MEDLINE
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