Elevated expression of N-myc downstream regulated gene 1 protein in glioblastomas reflects tumor angiogenesis and poor patient prognosis.

Autor: Sugita Y; Department of Neuropathology, Neurology Center, St. Mary's Hospital, Kurume, Japan., Furuta T; Department of Pathology, Kurume University School of Medicine, Kurume, Japan., Takahashi K; Department of Neurosurgery, Neurology Center, St. Mary's Hospital, Kurume, Japan., Higaki K; Department of Pathology, St. Mary's Hospital, Kurume, Japan., Murakami Y; Basic Medical Research Unit, St. Mary's Research Center, Kurume, Japan., Kuwano M; Basic Medical Research Unit, St. Mary's Research Center, Kurume, Japan., Ono M; Basic Medical Research Unit, St. Mary's Research Center, Kurume, Japan., Abe H; Department of Surgical Pathology, Kurume University School of Medicine, Kurume, Japan., Akiba J; Department of Surgical Pathology, Kurume University School of Medicine, Kurume, Japan., Morioka M; Department of Neurosurgery, Kurume University School of Medicine, Kurume, Japan.
Jazyk: angličtina
Zdroj: Neuropathology : official journal of the Japanese Society of Neuropathology [Neuropathology] 2024 Aug 06. Date of Electronic Publication: 2024 Aug 06.
DOI: 10.1111/neup.12999
Abstrakt: N-myc downstream regulated gene 1 (NDRG1) is a member of the NDRG family, of which four members (NDRG1, NDRG2, NDRG3, and NDRG4) have been identified. NDRG1 is repressed by c-MYC and N-MYC proto-oncogenes. NDRG1 is translated into a 43 kDa protein that is associated with the regulation of cellular stress responses, proliferation, and differentiation. In this study, we aimed to clarify the relationship between progression of glioblastoma (GB) IDH-wildtype and NDRG1 expression in tumor cells. We assessed the expression of NDRG1 in 41 GBs using immunostaining and evaluated its prognostic significance. NDRG1 expression by GBs was evaluated using Histoscore, which showed high and low scores in 23 and 18 cases, respectively. NDRG1-positive cells were strongly expressed in Ki-67 labeled proliferating tumor cells and CD105 positive proliferating microvessels around the area of palisading necrosis. Statistical analyses showed lower survival rates in the high-score group than the low-score group (P < 0.01). This study indicated that overexpression of NDRG1 by GB reflects tumor angiogenesis and poor patient prognosis.
(© 2024 Japanese Society of Neuropathology.)
Databáze: MEDLINE
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