Supramolecular J- and H-Aggregation of Naphthalimide-Conjugated Dipeptide in Mixed-Solvent Systems and its Application in Cell Imaging.

Autor: Kuila S; Department of Chemistry, University of North Bengal, Raja Rammohanpur, Siliguri, West Bengal, PIN-734013, India., Reddy KP; Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Kolkata (NIPER-K), Chunilal Bhawan, 168, Maniktala Main Road, Kolkata, West Bengal, PIN-700054, India., Dasgupta S; Centre for Healthcare Science and Technology, Indian Institution of Engineering Science and Technology, Shibpur, P.O. - Botanic Garden, Howrah, India., Bera A; Department of Physics, Midnapore College (Autonomus), Raja Bazar Main Road, Midnapore, West Bengal, PIN-721101, India., Mukherjee M; UGC-DAE Consortium For Scientific Research, Kolkata Centre, Sector III, LB-8, Bidhan Nagar, Kolkata, PIN-700 106, West Bengal, India., Pramanik G; UGC-DAE Consortium For Scientific Research, Kolkata Centre, Sector III, LB-8, Bidhan Nagar, Kolkata, PIN-700 106, West Bengal, India., Datta P; Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Kolkata (NIPER-K), Chunilal Bhawan, 168, Maniktala Main Road, Kolkata, West Bengal, PIN-700054, India., Nanda J; Department of Chemistry, University of North Bengal, Raja Rammohanpur, Siliguri, West Bengal, PIN-734013, India.
Jazyk: angličtina
Zdroj: Chemistry, an Asian journal [Chem Asian J] 2024 Aug 06, pp. e202400755. Date of Electronic Publication: 2024 Aug 06.
DOI: 10.1002/asia.202400755
Abstrakt: In this work, a core-substituted NMI-conjugated dipeptide (4MNLV) was extensively studied in mixed solvent systems to explore the polarity effect on the self-assembly pattern and their photophysical property. 4MNLV adopted J- or H- type aggregation pattern depending upon the polarity index of the solvent system chosen. The self-assembly process was achieved through the anti-solvent effect. UV-vis study suggested that if the stock solution of 4MNLV was diluted with a relatively more polar solvent (compared to the stock solvent), then the system acquired J- type of aggregation pattern by showing a red-shift in their absorption maxima (λ max ). Conversely, when the stock was diluted by a relatively less polar solvent, H-type of aggregation was observed, where blue shift of λ max was noticed. The emission spectra and the lifetime of the self-assembled materials were also influenced by the chosen solvent system. The chirotopic behaviour of these self-assembled materials was studied through CD spectroscopy. Morphological study indicated the formation of helical nanofibrillar structures. The bright green fluorescence of these highly biocompatible naphthalimide-peptide conjugate was used for cell imaging application, indicating its futuristic scope.
(© 2024 Wiley-VCH GmbH.)
Databáze: MEDLINE
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