Air travel in patients suffering from pulmonary hypertension-A prospective, multicentre study.

Autor: Yogeswaran A; Department of Internal Medicine, Justus-Liebig-University Giessen Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL) Giessen Germany., Grimminger J; Department of Internal Medicine, Justus-Liebig-University Giessen Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL) Giessen Germany., Tello K; Department of Internal Medicine, Justus-Liebig-University Giessen Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL) Giessen Germany., Becker L; Department of Internal Medicine, Justus-Liebig-University Giessen Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL) Giessen Germany., Seeger W; Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC) Institute for Lung Health (ILH), Cardio-Pulmonary Institute (CPI), Member of the German Center for Lung Research (DZL) Giessen Germany., Grimminger F; Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC) Institute for Lung Health (ILH), Cardio-Pulmonary Institute (CPI), Member of the German Center for Lung Research (DZL) Giessen Germany., Sommer N; Department of Internal Medicine, Justus-Liebig-University Giessen Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL) Giessen Germany., Ghofrani HA; Department of Internal Medicine, Justus-Liebig-University Giessen Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL) Giessen Germany., Lange TJ; Department of Internal Medicine II, Pulmonology and Intensive Care Kreisklinik Bad Reichenhall Bad Reichenhall Germany.; Department of Internal Medicine II, Faculty of Medicine Regensburg University Regensburg Germany., Stadler S; Department of Internal Medicine II University Medical Center Regensburg Regensburg Germany., Olsson K; Department of Respiratory Medicine and Infectious Diseases Hannover Medical School Hannover Germany.; Member of the German Center for Lung Research (DZL) Biomedical Research in Endstage and Obstructive Lung Disease Hanover (BREATH) Hannover Germany., Kamp JC; Department of Respiratory Medicine and Infectious Diseases Hannover Medical School Hannover Germany.; Member of the German Center for Lung Research (DZL) Biomedical Research in Endstage and Obstructive Lung Disease Hanover (BREATH) Hannover Germany., Rosenkranz S; Klinik III für Innere Medizin Herzzentrum der Universität zu Köln Cologne Germany., Gerhardt F; Klinik III für Innere Medizin Herzzentrum der Universität zu Köln Cologne Germany., Milger K; Department of Medicine V, LMU University Hospital, LMU Munich, Comprehensive Pneumology Center Member of the German Center for Lung Research (DZL) Giessen Germany., Barnikel M; Department of Medicine V, LMU University Hospital, LMU Munich, Comprehensive Pneumology Center Member of the German Center for Lung Research (DZL) Giessen Germany., Ulrich S; Department of Respiratory Medicine, Pulmonary Hypertension Unit University Hospital Zurich Zurich Switzerland., Saxer S; Department of Respiratory Medicine, Pulmonary Hypertension Unit University Hospital Zurich Zurich Switzerland., Grünig E; Thoraxklinik-Heidelberg gGmbH German Center for Lung Research (DZL) Heidelberg Germany., Harutynova S; Thoraxklinik-Heidelberg gGmbH German Center for Lung Research (DZL) Heidelberg Germany., Opitz C; Department of Cardiology DRK Kliniken Berlin Westend Berlin Germany., Klose H; Department of Respiratory Medicine Eppendorf University Hospital Hamburg Germany., Wilkens H; Klinik fur Innere Medizin V, Pneumologie Universitätsklinikum des Saarlandes Homburg Germany., Halank M; Internal Medicine I-Department of Pneumology University Hospital Carl Gustav Carus of TU Dresden Germany., Heberling M; Internal Medicine I-Department of Pneumology University Hospital Carl Gustav Carus of TU Dresden Germany., Gall H; Department of Internal Medicine, Justus-Liebig-University Giessen Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL) Giessen Germany., Richter MJ; Department of Internal Medicine, Justus-Liebig-University Giessen Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL) Giessen Germany.
Jazyk: angličtina
Zdroj: Pulmonary circulation [Pulm Circ] 2024 Aug 05; Vol. 14 (3), pp. e12397. Date of Electronic Publication: 2024 Aug 05 (Print Publication: 2024).
DOI: 10.1002/pul2.12397
Abstrakt: The PEGASUS study is the first multicentric and prospective assessment of the safety of air travel flying in pulmonary hypertension (PH) (NCT03051763). Data of air travel from 60 patients with PH was available. No severe adverse events occurred. Nine patients self-reported mild adverse events during flight (13%), while after landing, 12 patients reported events (20%). Solely one patient (2%) had an adverse event leading to medical consultation. In patients with PH and World Health Organization functional classes II and III, air travel was safe.
Competing Interests: Henning Gall reports grants from the German Research Foundation and nonfinancial support from the University of Giessen during the conduct of the study, and personal fees from Actelion, AstraZeneca, Bayer, BMS, GSK, Janssen‐Cilag, Lilly, MSD, Novartis, OMT, Pfizer, and United Therapeutics outside the submitted work. Athiththan Yogeswaran reports non‐financialnonfinancial support from the University of Giessen during the conduct of the study. Natascha Sommer reports personal fees from Actelion outside the submitted work. Hossein A. Ghofrani reports grants from the German Research Foundation and nonfinancial support from the University of Giessen during the conduct of the study, and personal fees from Bayer, Actelion, Pfizer, Merck, GSK, and Takeda, grants and personal fees from Novartis, Bayer HealthCare, and Encysive/Pfizer, and grants from Aires, the German Research Foundation, Excellence Cluster Cardiopulmonary Research, and the German Ministry for Education and Research outside the submitted work. Werner Seeger reports grants from the German Research Foundation and nonfinancial support from the University of Giessen during the conduct of the study, and personal fees from Pfizer and Bayer Pharma AG outside the submitted work. Manuel J. Richter reports grants from the German Research Foundation and nonfinancial support from the University of Giessen during the conduct of the study, and grants from United Therapeutics, grants and personal fees from Bayer, and personal fees from Actelion, Mundipharma, Roche, and OMT outside the submitted work. Khodr Tello reports grants from the German Research Foundation and nonfinancial support from the University of Giessen during the conduct of the study, and personal fees from Actelion and Bayer outside the submitted work. Heinrike Wilkens received fees for lectures and/or consultations from Actelion, AOP, Bayer, Biotest, Boehringer‐Ingelheim, Daiichi Sankyo, Ferrer, GSK, Janssen Cilag, and MSD outside the submitted work. Michael Halank reports personal fees from AstraZeneca, Janssen‐Cilag, and MSD outside the submitted work. Melanie Heberling reports personal fees from Janssen‐Cilag und MSD outside the submitted work. Dr. Ulrich receives research grants from the Swiss National Science Foundation, Zurich and Swiss Lung League, Orpha‐Swiss, Emdo Foundation and travel support, lecture fees, and advisory compensation from MSD SA, Orpha Swiss, Janssen SA, Novartis SA, all unrelated to the present work. Katrin Milger reports speaker and/or advisory board honoraria from AOP Pharma, Ferrer, Janssen, MSD. Tobias J. Lange reports personal fees from Acceleron Pharma, AstraZeneca, Bayer, Böhringer Ingelheim, Ferrer, Gossamer Bio, Janssen Cilag, MSD, Orphacare, and Pfizer. Stefan Stadler reports personal fees from Acceleron Pharma, AOP Health, Gossamer Bio, Janssen Cilag, MSD, and Pfizer. Jan C. Kamp is supported by PRACTIS—Clinician Scientist Program of Hannover Medical School, funded by the German Research Foundation, grant no. ME 3696/3‐1, KFO311— 286251789. Ekkehard Grünig has received fees for lectures and/or consultations from Actelion, Bayer/MSD, Ferrer, GEBRO, GSK, Janssen, and OMT. Research grants to his institution have been received from Acceleron, Actelion, BayerHealthCare, MSD, Bellerophon, GossamerBio, GSK, Janssen, Novartis, OMT, Pfizer, REATE, and United Therapeutics outside the submitted work. Satenik Harutynova has received support from Janssen, OMT, Bayer Pharma, GSK and speaker fees from Janssen and OMT outside submitted work. Karen Olsson has received fees for lectures and/or consultations from Acceleron, Actelion, AOP, MSD, Ferrer, Janssen, and OMT. Research grants to her institution have been received from Actelion, all outside the submitted work. All other authors declare no conflicts of interest.
(© 2024 The Author(s). Pulmonary Circulation published by John Wiley & Sons Ltd on behalf of Pulmonary Vascular Research Institute.)
Databáze: MEDLINE
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