Association Between Right Bundle Branch Block and Ventricular Arrhythmia in Patients With Cardiac Sarcoidosis.
| Autor: | Yamada Y; Department of Cardiology, Institute of Medicine; University of Tsukuba, Tsukuba, Japan., Sato K; Department of Cardiology, Institute of Medicine; University of Tsukuba, Tsukuba, Japan., Yamamoto M; Department of Cardiology, Institute of Medicine; University of Tsukuba, Tsukuba, Japan., Nabeta T; Department of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, Japan., Naruse Y; Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan., Taniguchi T; Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan., Kitai T; Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.; Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan., Yoshioka K; Department of Cardiology, Kameda Medical Center, Kamogawa, Japan., Tanaka H; Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan., Okumura T; Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Baba Y; Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University, Nankoku, Japan., Fujimoto Y; Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Hongo, Japan., Matsue Y; Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Hongo, Japan., Komatsu Y; Department of Cardiology, Institute of Medicine; University of Tsukuba, Tsukuba, Japan., Nogami A; Department of Cardiology, Institute of Medicine; University of Tsukuba, Tsukuba, Japan., Ishizu T; Department of Cardiology, Institute of Medicine; University of Tsukuba, Tsukuba, Japan. |
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| Jazyk: | angličtina |
| Zdroj: | JACC. Advances [JACC Adv] 2024 Jul 12; Vol. 3 (8), pp. 101105. Date of Electronic Publication: 2024 Jul 12 (Print Publication: 2024). |
| DOI: | 10.1016/j.jacadv.2024.101105 |
| Abstrakt: | Background: Ventricular arrhythmia (VA) is a life-threatening condition associated with cardiac sarcoidosis (CS). Right bundle branch block (RBBB) is a common conduction disorder in CS; however, its association with VA remains unknown. Objectives: This study aimed to investigate the relationship between RBBB and VA in patients with CS. Methods: This was a post hoc analysis of ILLUMINATE-CS (Illustration of the Management and Prognosis of Japanese Patients with Cardiac Sarcoidosis), a multicenter, retrospective, and observational study that evaluated the clinical characteristics and prognosis of CS. Eligible patients were divided into two groups based on the presence or absence of RBBB at the time of diagnosis. The primary outcome was serious ventricular arrhythmia events (SVAEs), defined as a combination of sudden cardiac death and documented ventricular fibrillation, sustained ventricular tachycardia, or appropriate implantable cardioverter-defibrillator therapy. Results: Overall, 312 patients were studied, with 155 (49.7%) patients presenting with RBBB (RBBB group). Patients in the RBBB group had a higher prevalence of basal interventricular septum (IVS) thinning and prominent late gadolinium enhancement in the basal IVS on cardiac magnetic resonance imaging than those in the non-RBBB group. During a median follow-up of 3.0 years (IQR: 1.6-6.0 years), 66 patients experienced SVAE. In multivariable Cox regression analysis, the RBBB group was independently associated with a higher incidence of SVAEs (HR: 1.93 [95% CI: 1.14-3.28]; P = 0.015). Conclusions: In patients with CS, RBBB was an independent predictor of SVAEs, which might reflect the specific scar distribution that is predominant in the IVS. Competing Interests: Dr Sato belongs to an endowed department funded by Medtronic and DVX. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. (© 2024 The Authors.) |
| Databáze: | MEDLINE |
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