An Interesting Case of Paroxysmal Nocturnal Hemoglobinuria With Renal Involvement.

Autor:	Keating S; Internal Medicine, Ocean University Medical Center, Brick, USA., Machchhar R; Internal Medicine, Ocean University Medical Center, Brick, USA., Jain U; Internal Medicine, Ocean University Medical Center, Brick, USA., Naronowicz G; Internal Medicine, Ocean University Medical Center, Brick, USA., Lipschutz J; Internal Medicine, Ocean University Medical Center, Brick, USA.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Jul 05; Vol. 16 (7), pp. e63917. Date of Electronic Publication: 2024 Jul 05 (Print Publication: 2024).
DOI:	10.7759/cureus.63917
Abstrakt:	Paroxysmal nocturnal hemoglobinuria (PNH) is an uncommon genetic disorder that affects red blood cell production, causing symptoms like fatigue, abdominal pain, and shortness of breath. This condition can also result in dark urine and an increased risk of infections. Diagnosis of PNH involves genetic testing and flow cytometry, which can confirm the presence of the condition. Once a diagnosis is confirmed, personalized treatment plans should be developed to effectively manage the symptoms and improve the patient's quality of life. Treatment options for PNH may include bone marrow transplantation, blood transfusions, and the use of recombinant monoclonal antibody, eculizumab. Regular monitoring is also essential to identify and manage any complications that may arise due to this condition. With proper management and treatment, patients with PNH can lead a healthy and fulfilling life. In this case study, we present a young adult male with PNH who also suffers from renal failure, highlighting the importance of personalized care and ongoing monitoring for this complex condition. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Keating et al.)
Databáze:	MEDLINE
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