The interaction between polyphenol intake and genes (MC4R, Cav-1, and Cry1) related to body homeostasis and cardiometabolic risk factors in overweight and obese women: a cross-sectional study.
| Autor: | Roumi Z; Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran., Mirzababaei A; Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran.; Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran., Abaj F; Department of Nutrition, Dietetics and Food, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia., Davaneghi S; MSC, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran., Aali Y; Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran.; Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran., Mirzaei K; Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Frontiers in nutrition [Front Nutr] 2024 Jul 22; Vol. 11, pp. 1410811. Date of Electronic Publication: 2024 Jul 22 (Print Publication: 2024). |
| DOI: | 10.3389/fnut.2024.1410811 |
| Abstrakt: | Background: Cardiovascular disease (CVD), which is an important global health challenge, is expanding. One of the main factors in the occurrence of CVD is a high genetic risk. The interaction between genetic risk in CVD and nutrition is debatable. Polyphenols are one of the important dietary components that may have a protective role in people who have a high genetic risk score (GRS) for cardiometabolic risk factors. This study, conducted in overweight and obese women, examines the interaction between polyphenol intake and specific genes (MC4r, Cav-1, and Cry1) related to maintaining body balance and their interaction with cardiometabolic risk factors. Methods: This cross-sectional study included 391 women who were overweight or obese, aged 18 to 48 years, with a body mass index (BMI) between 25 and 40 kg/m 2 . Body composition was measured using the InBody 770 scanner. Total dietary polyphenol intake (TDPI) was assessed with a validated 147-item food frequency questionnaire (FFQ), and polyphenol intakes were determined using the Phenol-Explorer database. Serum samples underwent biochemical tests. The Genetic Risk Score (GRS) was calculated based on the risk alleles of three genes: MC4r, Cav-1, and Cry1. Results: The mean ± standard deviation (SD) age and BMI of women were 36.67 (9.1) years and 30.98 (3.9) kg/m 2 , respectively. The high GRS and high TDPI group had a significant negative interaction with fasting blood glucose (FBS) ( p = 0.01). Individuals who had a high GRS and a high phenolic acid intake were found to have a significant negative interaction with Triglyceride ( p = 0.04). Similarly, individuals with high GRS and a high intake of flavonoids had a significant negative interaction with TG ( p < 0.01) and a significant positive interaction with High-density lipoprotein (HDL) ( p = 0.01) in the adjusted model. Conclusion: According to our findings, those with a high GRS may have a protective effect on cardiometabolic risk factors by consuming high amounts of polyphenols. Further studies will be necessary in the future to validate this association. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Roumi, Mirzababaei, Abaj, Davaneghi, Aali and Mirzaei.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|