Dos and don'ts to optimize transnasal aerosol drug delivery in clinical practice.

Autor:	Ari A; College of Health Professions, Department of Respiratory Care, Texas State University, Round Rock, TX, USA., Hoops JA; College of Health Professions, Department of Respiratory Care, Texas State University, Round Rock, TX, USA., Koyuncu A; Bioengineering Division, College of Engineering, Hacettepe University, Ankara, Turkey., Fink JB; College of Health Professions, Department of Respiratory Care, Texas State University, Round Rock, TX, USA.
Jazyk:	angličtina
Zdroj:	Expert opinion on drug delivery [Expert Opin Drug Deliv] 2024 Jul; Vol. 21 (7), pp. 1103-1114. Date of Electronic Publication: 2024 Aug 12.
DOI:	10.1080/17425247.2024.2388838
Abstrakt:	Introduction: Transnasal aerosol drug delivery has become widely accepted for treating acutely ill infants, children, and adults. More recently aerosol administration to wider populations receiving high and low-flow nasal oxygen has become common practice. Areas Covered: Skepticism of insufficient aerosol delivery to the lungs has been tempered by multiple in vitro explorations of variables to optimize delivery efficiency. Additionally, clinical studies demonstrated comparable clinical responses to orally inhaled aerosols. This paper provides essential clinical guidance on how to improve transnasal aerosol delivery based on device-, settings-, and drug-related optimization to serve as a resource for educational initiatives and quality enhancement endeavors at healthcare institutions. Expert Opinion: Transnasal aerosol delivery is proliferating worldwide, but indiscriminate use of excessive-high flows, poor selection and placement of aerosol devices and circuits can greatly reduce aerosol delivery and efficacy, potentially compromising treatment to acute and critically ill patients. Attention to these details can improve inhaled dose by an order of magnitude, making the difference between effective treatment and the progression to more invasive ventilatory support, with greater inherent risk and cost. These revelations have prompted specific recommendations for optimal delivery, driving advancements in aerosol generators, formulations, and future device designs to administer aerosols and maximize treatment effectiveness.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu