Breast multiparametric ultrasound: a single-center experience.

Autor: Zarcaro C; Section of Radiology, Department of Biomedicine, Neuroscience and Advanced Diagnostic (Bi.N.D.), University Hospital 'Policlinico P. Giaccone', Via Del Vespro 129, 90127, Palermo, Italy. calogerozarcaro@gmail.com., Orlando AAM; Section of Radiology, Department of Biomedicine, Neuroscience and Advanced Diagnostic (Bi.N.D.), University Hospital 'Policlinico P. Giaccone', Via Del Vespro 129, 90127, Palermo, Italy., Ferraro F; Section of Radiology, Department of Biomedicine, Neuroscience and Advanced Diagnostic (Bi.N.D.), University Hospital 'Policlinico P. Giaccone', Via Del Vespro 129, 90127, Palermo, Italy., Donia S; Section of Radiology, Department of Biomedicine, Neuroscience and Advanced Diagnostic (Bi.N.D.), University Hospital 'Policlinico P. Giaccone', Via Del Vespro 129, 90127, Palermo, Italy., Melita A; Section of Radiology, Department of Biomedicine, Neuroscience and Advanced Diagnostic (Bi.N.D.), University Hospital 'Policlinico P. Giaccone', Via Del Vespro 129, 90127, Palermo, Italy., Micci G; Section of Radiology, Department of Biomedicine, Neuroscience and Advanced Diagnostic (Bi.N.D.), University Hospital 'Policlinico P. Giaccone', Via Del Vespro 129, 90127, Palermo, Italy., Cannella R; Section of Radiology, Department of Biomedicine, Neuroscience and Advanced Diagnostic (Bi.N.D.), University Hospital 'Policlinico P. Giaccone', Via Del Vespro 129, 90127, Palermo, Italy., Bartolotta TV; Section of Radiology, Department of Biomedicine, Neuroscience and Advanced Diagnostic (Bi.N.D.), University Hospital 'Policlinico P. Giaccone', Via Del Vespro 129, 90127, Palermo, Italy.
Jazyk: angličtina
Zdroj: Journal of ultrasound [J Ultrasound] 2024 Dec; Vol. 27 (4), pp. 831-839. Date of Electronic Publication: 2024 Aug 05.
DOI: 10.1007/s40477-024-00944-2
Abstrakt: Purpose: To evaluate the role of multiparametric ultrasound (mpUS) in the characterization of focal breast lesions (FBLs).
Methods: This prospective study enrolled patients undergoing multiparametric breast ultrasound for FBLs. An experienced breast radiologist evaluated the following ultrasound features: US BI-RADS category, vascularization pattern (internal, vessels in rim and combined) and presence of penetrating vessels with each Doppler method (Color-Doppler, Power-Doppler, Microvascular imaging), strain ratio (SR) and Tsukuba score (TS) with Strain Elastography (SE), E max , E mean , E min and E ratio with 2D-shear wave elastography (2D-SWE). Core biopsy for all BI-RADS 4-5 FBLs and 24-month follow-up for all BI-RADS 2-3 FBLs were considered for standard of reference. The diagnostic performance was assessed with the area under curve (AUCs) and cut-off values were determined according to the Youden's index.
Results: A total of 139 FBLs were included with 75/139 (53.9%) benign and 64/139 (46.1%) malignant FBLs. Internal vascularization patterns (p < 0.001), penetrating vessels (p < 0.001), TS 4-5 (p < 0.001) and all 2D-SWE parameters (p < 0.001) were significantly different between benign and malignant FBLs. The BI-RADS score provided an AUC of 0.876 (95% CI 0.810-0.926) for the diagnosis of malignant FBLs. Among the 2D-SWE measurements, an excellent diagnostic performance was observed for E max with an AUC of 0.915 (95% CI 0.856-0.956) and E mean of 0.908 (95% CI 0.847-0.951). Optimal cutoff for the diagnosis of malignant FBLs were US BI-RADS > 3, Strain Ratio > 2.52, Tsukuba Score > 3, E max  > 82.6 kPa, E mean  > 66.0 kPa, E min  > 54.4 kPa and E ratio  > 330.8. Multiparametric ultrasound, particularly SWE, can improve specificity in the characterization of FBLs.
(© 2024. Società Italiana di Ultrasonologia in Medicina e Biologia (SIUMB).)
Databáze: MEDLINE
Externí odkaz: