Using a measurement type-independent metric to compare patterns of determinants between patient-reported versus performance-based physical function in hemodialysis patients.

Autor: Liegl G; Center for Patient-Centered Outcomes Research (CPCOR), Department of Psychosomatic Medicine, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, 10117, Berlin, Germany. Gregor.liegl@charite.de., Fischer FH; Center for Patient-Centered Outcomes Research (CPCOR), Department of Psychosomatic Medicine, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, 10117, Berlin, Germany., Canaud B; Global Medical Office, Fresenius Medical Care Deutschland GmbH, Bad Homburg, Germany.; School of Medicine, Montpellier University, Montpellier, France., Woodward M; School of Public Health, The George Institute for Global Health, Imperial College London, London, UK.; The George Institute for Global Health, University of New South Wales, Sydney, Australia., Barth C; Medical Scientific Affairs, B. Braun Avitum AG, Melsungen, Germany., Davenport A; Department of Renal Medicine, UCL, Royal Free Hospital & University College London, London, UK., Török M; Diaverum, Malmö, Sweden., Strippoli GFM; Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J) University of Bari, Italy & School of Public Health, University of Sydney, Darlington, Australia., Hegbrant J; Division of Nephrology, Department of Clinical Sciences, Lund University, Lund, Sweden., Cromm K; Center for Patient-Centered Outcomes Research (CPCOR), Department of Psychosomatic Medicine, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, 10117, Berlin, Germany.; Global Medical Office, Fresenius Medical Care Deutschland GmbH, Bad Homburg, Germany., Bots ML; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Blankestijn PJ; Department of Nephrology & Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands., Fischer KI; Center for Patient-Centered Outcomes Research (CPCOR), Department of Psychosomatic Medicine, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, 10117, Berlin, Germany., Rose M; Center for Patient-Centered Outcomes Research (CPCOR), Department of Psychosomatic Medicine, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, 10117, Berlin, Germany.
Jazyk: angličtina
Zdroj: Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation [Qual Life Res] 2024 Nov; Vol. 33 (11), pp. 2987-3001. Date of Electronic Publication: 2024 Aug 05.
DOI: 10.1007/s11136-024-03745-6
Abstrakt: Purpose: We applied a previously established common T-score metric for patient-reported and performance-based physical function (PF), offering the unique opportunity to directly compare measurement type-specific patterns of associations with potential laboratory-based, psychosocial, sociodemographic, and health-related determinants in hemodialysis patients.
Methods: We analyzed baseline data from the CONVINCE trial (N = 1,360), a multinational randomized controlled trial comparing high-flux hemodialysis with high-dose hemodiafiltration. To explore the associations of potential determinants with performance-based versus patient-reported PF, we conducted multiple linear regression (backward elimination with cross-validation and Lasso regression). We used standardized T-scores as estimated from the PROMIS PF short-form 4a (patient-reported PF) and the Physical Performance Test (performance-based PF) as dependent variables.
Results: Performance-based and patient-reported PF were both significantly associated with a laboratory marker-based indicator of muscle mass (simplified creatinine index), although the effects were relatively small (partial f 2  = 0.04). Age was negatively associated with PF; the effect size was larger for performance-based (partial f 2  = 0.12) than for patient-reported PF (partial f 2  = 0.08). Compared to performance-based PF, patient-reported PF showed a stronger association with self-reported health domains, particularly pain interference and fatigue. When using the individual difference between patient-reported and performance-based T-scores as outcome, we found that younger age and more fatigue were associated with lower patient-reported PF compared to performance-based PF (small effect size).
Conclusion: Patient-reported and performance-based assessments were similarly associated with an objective marker of physical impairment in hemodialysis patients. Age and fatigue may result in discrepancies when comparing performance-based and patient-reported scores on the common PF scale. Trial Registration CONVINCE is registered in the Dutch Trial Register (Register ID: NL64750.041.18). The registration can be accessed at: https://onderzoekmetmensen.nl/en/trial/52958 .
(© 2024. The Author(s).)
Databáze: MEDLINE
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