A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state.
Autor: | Knight KM; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, Jupiter, FL, USA., Krumm BE; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Kapolka NJ; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Ludlam WG; Department of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, Jupiter, FL, USA., Cui M; Department of Pharmaceutical Sciences Northeastern University, Boston, MA, USA., Mani S; Department of Pharmaceutical Sciences Northeastern University, Boston, MA, USA., Prytkova I; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Obarow EG; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Lefevre TJ; Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA., Wei W; Department of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, CA, USA., Ma N; Department of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, CA, USA., Huang XP; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Fay JF; Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, Baltimore, Baltimore, MD, USA., Vaidehi N; Department of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, CA, USA., Smrcka AV; Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA., Slesinger PA; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Logothetis DE; Department of Pharmaceutical Sciences Northeastern University, Boston, MA, USA., Martemyanov KA; Department of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, Jupiter, FL, USA., Roth BL; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Dohlman HG; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. hdohlman@med.unc.edu. |
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Jazyk: | angličtina |
Zdroj: | Nature communications [Nat Commun] 2024 Aug 05; Vol. 15 (1), pp. 6643. Date of Electronic Publication: 2024 Aug 05. |
DOI: | 10.1038/s41467-024-50964-z |
Abstrakt: | Many neurotransmitter receptors activate G proteins through exchange of GDP for GTP. The intermediate nucleotide-free state has eluded characterization, due largely to its inherent instability. Here we characterize a G protein variant associated with a rare neurological disorder in humans. Gα (© 2024. The Author(s).) |
Databáze: | MEDLINE |
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