Allium cepa as a Toxicogenetic Investigational Tool for Plant Extracts: A Systematic Review.

Autor: Melo EC; Laboratory of Genetics and Molecular Biology - Federal Institute of Piauí (IFPI), 64001-270, Teresina, Piauí, Brazil., Pinheiro RDS; Laboratory of Genetics and Molecular Biology - Federal Institute of Piauí (IFPI), 64001-270, Teresina, Piauí, Brazil., Costa BS; Laboratory of Genetics and Molecular Biology - Federal Institute of Piauí (IFPI), 64001-270, Teresina, Piauí, Brazil., Lima RMT; Laboratory of Genetics and Molecular Biology - Federal Institute of Piauí (IFPI), 64001-270, Teresina, Piauí, Brazil.; Northeast Biotechnology Network (RENORBIO), Postgraduate Program in Biotechnology, Federal University of Piauí - IFPI, 64049-550, Teresina, Piauí, Brazil.; Laboratory of Genetics and Toxicology-LAPGENIC, Post-Graduate Program in Pharmaceutical Science, Federal University of Piauí, 64049-550, Teresina, Piauí, Brazil., Dias ACS; Laboratory of Genetics and Molecular Biology, Federal University of Maranhão, Bacanga, 65080-805, São Luís, Maranhão, Brazil., de Jesus Aguiar Dos Santos T; Nucleus of Applied Research to Sciences (NIAC), Federal Institute of Maranhão, 65630-000, Campus Presidente Dutra, MA, Brazil., Nascimento MLLBD; Laboratory of Genetics and Toxicology-LAPGENIC, Post-Graduate Program in Pharmaceutical Science, Federal University of Piauí, 64049-550, Teresina, Piauí, Brazil.; Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, 64049-550, Teresina, Piauí, Brazil., Sousa JMCE; Northeast Biotechnology Network (RENORBIO), Postgraduate Program in Biotechnology, Federal University of Piauí - IFPI, 64049-550, Teresina, Piauí, Brazil.; Laboratory of Genetics and Toxicology-LAPGENIC, Post-Graduate Program in Pharmaceutical Science, Federal University of Piauí, 64049-550, Teresina, Piauí, Brazil.; Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, 64049-550, Teresina, Piauí, Brazil., Islam MT; Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, 8100, Gopalganj, Bangladesh.; Pharmacy Discipline, Khulna University, 9208, Khulna, Bangladesh.; Bioinformatics and Drug Innovation Laboratory, BioLuster Research Center, 8100, Gopalganj, Bangladesh., Melo Cavalcante AAC; Northeast Biotechnology Network (RENORBIO), Postgraduate Program in Biotechnology, Federal University of Piauí - IFPI, 64049-550, Teresina, Piauí, Brazil.; Laboratory of Genetics and Toxicology-LAPGENIC, Post-Graduate Program in Pharmaceutical Science, Federal University of Piauí, 64049-550, Teresina, Piauí, Brazil., El-Nashar HAS; Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, 11566, Abbassia, Cairo, Egypt., El-Shazly M; Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, 11566, Abbassia, Cairo, Egypt., Oliveira Filho JWG; Laboratory of Genetics and Molecular Biology - Federal Institute of Piauí (IFPI), 64001-270, Teresina, Piauí, Brazil.; Northeast Biotechnology Network (RENORBIO), Postgraduate Program in Biotechnology, Federal University of Piauí - IFPI, 64049-550, Teresina, Piauí, Brazil.; Laboratory of Genetics and Toxicology-LAPGENIC, Post-Graduate Program in Pharmaceutical Science, Federal University of Piauí, 64049-550, Teresina, Piauí, Brazil.
Jazyk: angličtina
Zdroj: Chemistry & biodiversity [Chem Biodivers] 2024 Aug 05, pp. e202401406. Date of Electronic Publication: 2024 Aug 05.
DOI: 10.1002/cbdv.202401406
Abstrakt: Toxicological studies are important to investigate the genotoxic effects of various substances. Allium cepa can be used as test model for this purpose. This review summarizes the scope and applications for this A. cepa test model. For this, an up-to-date (April 2023) literature search was made in the Science Direct, PubMed, and Web of Science databases to find published evidence on studies performed using A. cepa as a test model. Out of 3,748 studies, 74 fit the inclusion criteria. The results showed that the use of the test model A. cepa contributed considerably to measuring the toxicological potential of plant extracts, proving the efficacy of the test as a potent bioindicator of toxic effects. In addition, 27 studies used more than one test system to verify the toxicological potential of extracts and fractions. Studies have shown that the A. cepa model has the potential to replace other test systems that make use of animals and cell cultures, besides having other advantages such as low cost, ease of execution, and good conditions for the observation of chromosomes. In conclusion, the A. cepa test can be considered one of the potential biomonitoring systems in toxicological studies of crude extracts.
(© 2024 Wiley-VHCA AG, Zurich, Switzerland.)
Databáze: MEDLINE
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