Allium cepa as a Toxicogenetic Investigational Tool for Plant Extracts: A Systematic Review.

Autor: de Melo EC; Federal Institute of Education Science and Technology of Piaui, Laboratory of Genetics and Molecular Biology, brZIL, brazil, BRAZIL., da Silva Pinheiro R; Federal Institute of Education Science and Technology of Piaui, Laboratory of Genetics and Molecular Biology - Federal Institute of Piauí (IFPI), Teresina, Piauí 64001-270, Brazil, brazil, brazil, BRAZIL., Costa BS; Federal Institute of Education Science and Technology of Piaui, Genetics and Molecular Biology, brazil, brazil, BRAZIL., de Lima RMT; Federal Institute of Education Science and Technology of Piaui, Genetics and Molecular Biology, brazil, brazil, BRAZIL., Soares Dias AC; Federal Institute of Education Science and Technology of Maranhão, Genetics and Molecular Biology, brazil, brazil, BRAZIL., Dos Santos TJA; Federal Institute of Education Science and Technology of Maranhão, applied science, brazil, brazil, BRAZIL., do Nascimento MLLB; Federal Institute of Education Science and Technology of Piaui, Pharmaceutical Sciences,, brazil, brazil, BRAZIL., de Castro E Sousa JM; Federal University of Piaui, 6Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Piauí, Teresina 64049-550, Brazil, brazil, brazil, BRAZIL., Islam MT; Bangabandhu Sheikh Mujibur Rahman Science and Technology University, pharmacy, Department of Pharmacy, Gopalgong, 8100, Gopalgong, BANGLADESH., Cavalcante AACM; Federal University of Piaui, Biotechnology Network, brazil, brazil, BRAZIL., El-Nashar HAS; Ain Shams University Faculty of Pharmacy, pharmacognosy, Cairo, 16559, Cairo, EGYPT., El-Shazly M; Ain Shams University, pharmacognosy, cairo, cairo, EGYPT., de Oliveira Filho JWG; Federal University of Piaui, genetics, brazil, brazil, BRAZIL.
Jazyk: angličtina
Zdroj: Chemistry & biodiversity [Chem Biodivers] 2024 Aug 05, pp. e202401406. Date of Electronic Publication: 2024 Aug 05.
DOI: 10.1002/cbdv.202401406
Abstrakt: Toxicological studies are important to investigate the genotoxic effects of various substances. Allium cepa can be used as test model for this purpose. This review summarizes the scope and applications for this A. cepa test model. For this, an up-to-date (April 2023) literature search was made in the Science Direct, PubMed, and Web of Science databases to find published evidence on studies performed using A. cepa as a test model. Out of 3,748 studies, 74 fit the inclusion criteria. The results showed that the use of the test model A. cepa contributed considerably to measuring the toxicological potential of plant extracts, proving the efficacy of the test as a potent bioindicator of toxic effects. In addition, 27 studies used more than one test system to verify the toxicological potential of extracts and fractions. Studies have shown that the A. cepa model has the potential to replace other test systems that make use of animals and cell cultures, besides having other advantages such as low cost, ease of execution, and good conditions for the observation of chromosomes. In conclusion, the A. cepa test can be considered one of the potential biomonitoring systems in toxicological studies of crude extracts.
(© 2024 Wiley‐VCH GmbH.)
Databáze: MEDLINE
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