Pattern-reversal visual evoked potentials in prosthetic vision and simulated visual reduction.

Autor:	He Y; Department of Psychology, North Carolina State University, Raleigh, North Carolina, USA yhe29@ncsu.edu., Toft-Nielsen J; Department of Biomedical Engineering, University of Miami, Coral Gables, Florida, USA.; Intelligent Hearing Systems, Miami, Florida, USA., Legge G; Department of Psychology, University of Minnesota Twin Cities, Minneapolis, Minnesota, USA., Montezuma SR; Ophthalmology and Visual Neurosciences, University of Minnesota Twin Cities, Minneapolis, Minnesota, USA.
Jazyk:	angličtina
Zdroj:	BMJ open ophthalmology [BMJ Open Ophthalmol] 2024 Aug 05; Vol. 9 (1). Date of Electronic Publication: 2024 Aug 05.
DOI:	10.1136/bmjophth-2024-001705
Abstrakt:	Objective: To quantitatively evaluate visual evoked potentials (VEPs) in prosthetic vision and simulated visual reduction. Methods and Analysis: Four blind patients implanted with the Argus II retinal prosthesis and seven sighted controls participated. VEPs were recorded with pattern-reversal stimuli (2 cycles of a horizontal square wave grating, 0.1 cycle/degree) at 1.07 reversals per second (rps) for Argus II subjects and 3.37 rps for controls. Argus II patients had both eyes patched, viewing the pattern solely through their implant. Controls viewed the pattern monocularly, either with their best-corrected vision or with simulated visual reduction (field restriction, added blur or reduced display contrast). Results: VEPs recorded in Argus II patients displayed a similar shape to normal VEPs when controls viewed the pattern without simulated visual reduction. In sighted controls, adding blur significantly delayed the P100 peak time by 8.7 ms, 95% CI (0.9, 16.6). Reducing stimulus contrast to 32% and 6% of full display contrast significantly decreased P100 amplitude to 55% (37%, 82%) and 20% (13%, 31%), respectively. Restriction on the field of view had no impact on either the amplitude or the peak latency of P100. Conclusion: The early visual cortex in retinal prosthesis users remains responsive to retinal input, showing a similar response profile to that of sighted controls. Pattern-reversal VEP offers valuable insights for objectively evaluating artificial vision therapy systems (AVTSs) when selecting, fitting and training implant users, but the uncertainties in the exact timing and location of electrode stimulation must be considered when interpreting the results. Competing Interests: Competing interests: JT-N: Intelligent Hearing Systems and JÖRVEC; YH: none; GEL: none; SRM: none. (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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