Association of serum biomarkers with radiographic knee osteoarthritis, knee pain and function in a young, male, trauma-exposed population - Findings from the ADVANCE study.

Autor: O'Sullivan O; Academic Department of Military Rehabilitation (ADMR), Defence Medical Rehabilitation Centre (DMRC), Stanford Hall, Loughborough, UK; Academic Unit of Injury, Recovery and Inflammation Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, UK. Electronic address: oliver.o'sullivan@nhs.net., Stocks J; Academic Unit of Injury, Recovery and Inflammation Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, UK. Electronic address: Joanne.Stocks@nottingham.ac.uk., Schofield S; National Heart and Lung Institute, Imperial College London, London, UK. Electronic address: s.schofield@imperial.ac.uk., Bilzon J; Centre for Sport, Exercise and Osteoarthritis Research Versus Arthritis, University of Bath, Bath, UK; Department for Health, University of Bath, Bath, UK. Electronic address: j.bilzon@bath.ac.uk., Boos CJ; Academic Department of Military Rehabilitation (ADMR), Defence Medical Rehabilitation Centre (DMRC), Stanford Hall, Loughborough, UK; Faculty of Health & Social Sciences, Bournemouth University, Bournemouth, UK. Electronic address: Christopher.Boos@uhd.nhs.uk., Bull AMJ; Centre for Blast Injury Studies, Department of Bioengineering, Imperial College London, London, UK. Electronic address: a.bull@imperial.ac.uk., Fear NT; Academic Department of Military Mental Health, King's College London, London, UK. Electronic address: nicola.t.fear@kcl.ac.uk., Watt FE; Department of Immunology and Inflammation, Imperial College London, London, UK; Centre for Osteoarthritis Pathogenesis Versus Arthritis, Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK. Electronic address: f.watt@imperial.ac.uk., Bennett AN; Academic Department of Military Rehabilitation (ADMR), Defence Medical Rehabilitation Centre (DMRC), Stanford Hall, Loughborough, UK; National Heart and Lung Institute, Imperial College London, London, UK. Electronic address: Alexander.Bennett485@mod.gov.uk., Kluzek S; Academic Unit of Injury, Recovery and Inflammation Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, UK; Centre for Sport, Exercise and Osteoarthritis Research Versus Arthritis, University of Nottingham, Nottingham, UK. Electronic address: Stefan.Kluzek@nottingham.ac.uk., Valdes AM; Nottingham NIHR Biomedical Research Centre, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, UK; Department of Twin Research & Genetic Epidemiology, King's College London, London, UK. Electronic address: Ana.Valdes@nottingham.ac.uk.
Jazyk: angličtina
Zdroj: Osteoarthritis and cartilage [Osteoarthritis Cartilage] 2024 Aug 03. Date of Electronic Publication: 2024 Aug 03.
DOI: 10.1016/j.joca.2024.07.016
Abstrakt: Objective: The ArmeD SerVices TrAuma RehabilitatioN OutComE (ADVANCE) study is investigating long-term combat-injury outcomes; this sub-study aims to understand the association of osteoarthritis (OA) biomarkers with knee radiographic OA (rOA), pain and function in this high-risk population for post-traumatic OA.
Design: ADVANCE compares combat-injured participants with age, rank, deployment and job-role frequency-matched uninjured participants. Post-injury immunoassay-measured serum biomarkers, knee radiographs, Knee Injury and Osteoarthritis Outcome Scale, and six-minute walk tests are reported. The primary analysis, adjusted for age, body mass, socioeconomic status, and ethnicity, was to determine any differences in biomarkers between those with/without combat injury, rOA and pain. Secondary analyses were performed to compare post-traumatic/idiopathic OA, painful/painfree rOA and injury patterns.
Results: A total of 1145 male participants were recruited, aged 34.1 ± 5.4, 8.9 ± 2.2 years post-injury (n = 579 trauma-exposed, of which, traumatic-amputation n = 161) or deployment (n = 566 matched). Cartilage oligomeric matrix protein (COMP) was significantly higher in the combat-injured group compared to uninjured (p = 0.01). Notably, COMP was significantly lower in the traumatic-amputation group compared to non-amputees (p < 0.001), decreasing relative to number of amputations (p < 0.001). Leptin was higher (p = 0.005) and adiponectin lower (p = 0.017) in those with v without knee pain, associated with an increased risk of 22% and 17% for pain, and 46% and 34% for painful rOA, respectively. There were no significant differences between trauma-exposed and unexposed participants with rOA.
Conclusions: The most notable findings of this large, unique study are the similarities between those with rOA regardless of trauma-exposure, the injury-pattern and traumatic-amputation-associated differences in COMP, and the relationship between adipokines and pain.
(Crown Copyright © 2024. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE