Spider and scorpion knottins targeting voltage-gated sodium ion channels in pain signaling.

Autor: Wang X; College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan 410128, China., Luo H; College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan 410128, China., Peng X; School of Public Health & Laboratory Medicine, Hunan University of Medicine, Huaihua 418000, China. Electronic address: peng112112@163.com., Chen J; College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan 410128, China; Hunan Provincial Engineering Technology Research Center for Cell Mechanics and Function Analysis, Changsha 418000, China. Electronic address: jinjunchen@hunau.edu.cn.
Jazyk: angličtina
Zdroj: Biochemical pharmacology [Biochem Pharmacol] 2024 Sep; Vol. 227, pp. 116465. Date of Electronic Publication: 2024 Aug 03.
DOI: 10.1016/j.bcp.2024.116465
Abstrakt: In sensory neurons that transmit pain signals, whether acute or chronic, voltage-gated sodium channels (VGSCs) are crucial for regulating excitability. Na V 1.1, Na V 1.3, Na V 1.6, Na V 1.7, Na V 1.8, and Na V 1.9 have been demonstrated and defined their functional roles in pain signaling based on their biophysical properties and distinct patterns of expression in each subtype of sensory neurons. Scorpions and spiders are traditional Chinese medicinal materials, belonging to the arachnid class. Most of the studied species of them have evolved venom peptides that exhibit a wide variety of knottins specifically targeting VGSCs with subtype selectivity and conformational specificity. This review provides an overview on the exquisite knottins from scorpion and spider venoms targeting pain-related Na V channels, describing the sequences and the structural features as well as molecular determinants that influence their selectivity on special subtype and at particular conformation, with an aim for the development of novel research tools on Na V channels and analgesics with minimal adverse effects.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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