How do we classify organ involvement in Chagas disease? A systematic review of organ involvement since 1909, Highlighting the urgent need for a universal classification system in Chronic Chagas disease.

Autor: Losada Galván I; ISGlobal, Barcelona, Spain.; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), Barcelona, Spain.; Hospital Universitario 12 de Octubre, Madrid, Spain., García M; Hospital General Universitario de Valencia, Valencia, Spain., Hasslocher-Moreno AM; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Brazil., Ortiga A; ISGlobal, Barcelona, Spain., Sanz S; ISGlobal, Barcelona, Spain.; Department of Basic Clinical Practice, Faculty of Medicine, University of Barcelona.; CIBER Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Spain., Molina I; International Health Unit Vall d'Hebron-Drassanes, Infectious Diseases Department, Vall d'Hebron University Hospital, PROSICS Barcelona, Barcelona, Spain.; CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III (CIBERINFEC, ISCIII), Spain., Gascón J; ISGlobal, Barcelona, Spain.; CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III (CIBERINFEC, ISCIII), Spain., Pinazo MJ; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), Barcelona, Spain.; CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III (CIBERINFEC, ISCIII), Spain.; Drugs for Neglected Diseases initiative, Rio de Janeiro, Brasil.
Jazyk: angličtina
Zdroj: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2024 Aug 05; Vol. 18 (8), pp. e0012367. Date of Electronic Publication: 2024 Aug 05 (Print Publication: 2024).
DOI: 10.1371/journal.pntd.0012367
Abstrakt: Chagas disease (CD) is recognized as one of the 20 neglected tropical diseases by the World Health Organization (WHO), posing a significant global health challenge. The objective of this work was to conduct a systematic methodology review to explore the different classifications used to describe the presence and degree of organ involvement in patients with CD since the disease's description in 1909. We searched relevant electronic medical databases from their inception dates to July 2023. We also delved into historical variations and revisions of each classification, the necessary diagnostic methods, their prognostic value, and their uptake. Our study underscores the conspicuous absence of a universally accepted CD classification system for cardiac and digestive involvement, both in the context of clinical trials and within current clinical guidelines. This endeavour will facilitate cross-population comparisons if clinical manifestations and complementary test results are available for each patient, constituting a pivotal stride toward identifying precise prognoses and establishing a minimum data set requisite for a fitting CD classification, tailored to the test availability in both endemic and non-endemic regions.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Losada Galván et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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