The effect of intra spinal administration of cerium oxide nanoparticles on central pain mechanism: An experimental study.

Autor: Mostaar A; Department of Medical Physics and Biomedical Engineering, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Behroozi Z; Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran., MotamedNezhad A; College of Veterinary Medicine, Islamic Azad University, Karaj, Alborz, Iran., Taherkhani S; Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran., Mojarad N; Program in Neuroscience, Central Michigan University, Mt. Pleasant, MI, 48859, USA., Ramezani F; Physiology Research Center, , Iran University of Medical Sciences, Tehran, Iran. Ramezani.f@iums.ac.ir., Janzadeh A; Radiation Biology Research Center, Iran University of Medical Sciences, Tehran, Iran. janzadeh.at@iums.ac.ir., Hajimirzaie P; Radiation Biology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Jazyk: angličtina
Zdroj: Journal of bioenergetics and biomembranes [J Bioenerg Biomembr] 2024 Oct; Vol. 56 (5), pp. 505-515. Date of Electronic Publication: 2024 Aug 05.
DOI: 10.1007/s10863-024-10033-y
Abstrakt: This study investigated Cerium oxide nanoparticles (CeONPs) effect on central neuropathic pain (CNP). The compressive method of spinal cord injury (SCI) model was used for pain induction. Three groups were formed by a random allocation of 24 rats. In the treatment group, CeONPs were injected above and below the lesion site immediately after inducing SCI. pain symptoms were evaluated using acetone, Radian Heat, and Von Frey tests weekly for six weeks. Finally, we counted fibroblasts using H&E staining. We evaluated the expression of Cx43, GAD65 and HDAC2 proteins using the western blot method. The analysis of results was done by PRISM software. At the end of the study, we found that CeONPs reduced pain symptoms to levels similar to those observed in normal animals. CeONPs also increased the expression of GAD65 and Cx43 proteins but did not affect HDAC2 inhibition. CeONPs probably have a pain-relieving effect on chronic pain by potentially preserving GAD65 and Cx43 protein expression and hindering fibroblast infiltration.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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