Outcomes of Differentiated Thyroid Cancer in Children and Adolescents at King Abdulaziz Medical City, Jeddah.

Autor:	Nasser T; College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, SAU.; Department of Medicine/Endocrinology, King Abdullah International Medical Research Center, Jeddah, SAU.; Department of Medicine/Endocrinology, King Abdulaziz Medical City, Jeddah, SAU., Altirkistani BA; College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, SAU.; Department of Medicine/Endocrinology, King Abdullah International Medical Research Center, Jeddah, SAU., Bougis SM; College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, SAU.; Department of Medicine/Endocrinology, King Abdullah International Medical Research Center, Jeddah, SAU., Abu Ghasham AH; College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, SAU.; Department of Medicine/Endocrinology, King Abdullah International Medical Research Center, Jeddah, SAU., Nafadi IB; College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, SAU.; Department of Medicine/Endocrinology, King Abdullah International Medical Research Center, Jeddah, SAU.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Aug 02; Vol. 16 (8), pp. e65992. Date of Electronic Publication: 2024 Aug 02 (Print Publication: 2024).
DOI:	10.7759/cureus.65992
Abstrakt:	Objective Differentiated thyroid cancer (DTC) is rare in the pediatric population, with most data from the Western world. We aimed to describe the clinical presentation, treatment intervention, histopathological characteristics, complications, follow-up, and response to treatment in 17 patients with DTC at or below the age of 20 years. Interventions This was a retrospective cohort study at King Abdulaziz Medical City, Jeddah, Saudi Arabia. We included patients aged younger than 20 years with DTC. Total or near-total thyroidectomy was performed in 82% of the patients, central and/or lateral neck dissection in 35% of cases, and radioactive iodine (RAI) ablation in 76% of cases. Results The study included 17 patients (14 females), with a median age of 16 years at the time of diagnosis. Thyroid nodules were the main complaint in 88% of the patients. Thyroid ultrasonography was the main method for the initial evaluation. Papillary cancer was the most common type of tumor, and lymph node spread was found in 82% of the patients. Moreover, 40% of the patients exhibited excellent responses to therapy, with 35% showing indeterminate results. Only 23.5% of the patients developed hypocalcemia postoperatively. Conclusions Classical papillary thyroid carcinoma was the predominant histopathological type, and most patients showed excellent responses to therapy, followed by indeterminate in most of the cases. The most common presentation was a neck nodule, signifying the role of thorough physical neck examinations. Finally, recurrence occurred in a minority of patients. However, none of these patients died. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. The Institutional Review Board of King Abdullah Medical City issued approval NRJ21J/197/08. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Nasser et al.)
Databáze:	MEDLINE
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