Risk factors, incidence, and outcomes of neonatal respiratory extracorporeal membrane oxygenation including association with therapeutic hypothermia in California during 2013-2020.

Autor: Sankaran D; Division of Neonatology, Department of Pediatrics, University of California Davis, Sacramento, CA, USA. dsankaran@ucdavis.edu., Lee HC; Division of Neonatology, Department of Pediatrics, University of California San Diego, La Jolla, CA, USA., Park L; Division of Neonatology, Department of Pediatrics, University of California Davis, Sacramento, CA, USA., Kan P; Division of Neonatology, Department of Pediatrics, Stanford University, Palo Alto, CA, USA., Lakshminrusimha S; Division of Neonatology, Department of Pediatrics, University of California Davis, Sacramento, CA, USA.
Jazyk: angličtina
Zdroj: Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] 2024 Oct; Vol. 44 (10), pp. 1442-1447. Date of Electronic Publication: 2024 Aug 04.
DOI: 10.1038/s41372-024-02067-2
Abstrakt: Objective: To evaluate the incidence, indications and outcomes with neonatal extracorporeal membrane oxygenation (ECMO) and its association with therapeutic hypothermia (TH) among infants undergoing invasive mechanical ventilation (IMV) in California during 2013-2020.
Study Design: We analyzed data on neonates ≥34 weeks gestation with ≥4 h of IMV over an 8-year period (2013-2020) from the California Perinatal Quality Care Collaborative (CPQCC) database.
Results: Between 2013 and 2020, the ranges for utilization of iNO (13.9 to 17.2%), ECMO (2.1 to 2.5%), TH (10.2 to 15.7%) and TH + ECMO (0.4 to 0.8%) were observed. The most common association with neonatal ECMO was TH (148 cases, OR 3.2, 95% CI 2.6-4.3, p < 0.01). The combination of meconium aspiration syndrome (MAS) and hypoxic ischemic encephalopathy (HIE) increased risk of iNO and ECMO use (OR 11.3, 1.5-86.9), p = 0.02).
Conclusion: Ventilated infants ≥34 weeks gestational age undergoing TH are at risk for iNO/ECMO use and need close monitoring.
(© 2024. The Author(s), under exclusive licence to Springer Nature America, Inc.)
Databáze: MEDLINE
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