The role of polypeptides encoded by ncRNAs in cancer.

Autor: Huang J; Lab for Noncoding RNA & Cancer, School of Life Sciences, Shanghai University, Shanghai 200444, China., Yang P; Department of Gynecology, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Kunming 650118,China., Pan W; Lab for Noncoding RNA & Cancer, School of Life Sciences, Shanghai University, Shanghai 200444, China., Wu F; Lab for Noncoding RNA & Cancer, School of Life Sciences, Shanghai University, Shanghai 200444, China., Qiu J; Department of Anesthesiology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 201800, China. Electronic address: qiujianhuacml@163.com., Ma Z; Lab for Noncoding RNA & Cancer, School of Life Sciences, Shanghai University, Shanghai 200444, China. Electronic address: zlma@shu.edu.cn.
Jazyk: angličtina
Zdroj: Gene [Gene] 2024 Nov 30; Vol. 928, pp. 148817. Date of Electronic Publication: 2024 Aug 03.
DOI: 10.1016/j.gene.2024.148817
Abstrakt: It was previously thought that ncRNA could not encode polypeptides, but recent reports have challenged this notion. As research into ncRNA progresses, it is increasingly clear that it serves roles beyond traditional mechanisms, playing significant regulatory roles in various diseases, notably cancer, which is responsible for 70% of human deaths. Numerous studies have highlighted the diverse regulatory mechanisms of ncRNA that are pivotal in cancer initiation and progression. The role of ncRNA-encoded polypeptides in cancer regulation has gained prominence. This article explores the newly identified regulatory functions of these polypeptides in three types of ncRNA-lncRNA, pri-miRNA, and circRNA. These polypeptides can interact with proteins, influence signaling pathways, enhance miRNA stability, and regulate cancer progression, malignancy, resistance, and other clinical challenges. Furthermore, we discuss the evolutionary significance of these polypeptides in the transition from RNA to protein, examining their emergence and conservation throughout evolution.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier B.V.)
Databáze: MEDLINE
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