Piperlongumine inhibits the early stage of adipogenesis in 3T3-L1 cells.

Autor: Piao M; College of Pharmacy, Research Institute of Pharmaceutical Sciences, Chonnam National University, Gwangju, 500-757, Republic of Korea., Jin Y; College of Pharmacy, Research Institute of Pharmaceutical Sciences, Chonnam National University, Gwangju, 500-757, Republic of Korea., Jin S; College of Pharmacy, Research Institute of Pharmaceutical Sciences, Chonnam National University, Gwangju, 500-757, Republic of Korea., Min J; College of Pharmacy, Research Institute of Pharmaceutical Sciences, Chonnam National University, Gwangju, 500-757, Republic of Korea., Lee SH; College of Pharmacy, Research Institute of Pharmaceutical Sciences, Chonnam National University, Gwangju, 500-757, Republic of Korea., Cho YC; College of Pharmacy, Research Institute of Pharmaceutical Sciences, Chonnam National University, Gwangju, 500-757, Republic of Korea. Electronic address: yccho@jnu.ac.kr., Lee KY; College of Pharmacy, Research Institute of Pharmaceutical Sciences, Chonnam National University, Gwangju, 500-757, Republic of Korea. Electronic address: kwanglee@jnu.ac.kr.
Jazyk: angličtina
Zdroj: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2024 Nov 26; Vol. 735, pp. 150458. Date of Electronic Publication: 2024 Jul 30.
DOI: 10.1016/j.bbrc.2024.150458
Abstrakt: Piperlongumine (PLM), a natural compound isolated from long peppers, has been reported to possess multiple pharmacological roles, including anti-tumor and anti-diabetic. However, the pharmacological role of PLM on adipogenesis is still unknown. In this study, we found that PLM strongly inhibited 3T3-L1 adipocyte differentiation. This inhibition was determined by the accumulation of lipid droplets and intracellular triglycerides. In addition, PLM downregulated both the mRNA and protein expression of adipogenic transcription factors, including CCAAT-enhancer binding proteins β (C/EBPβ), C/EBPα, and peroxisome proliferator-activated receptor γ (PPARγ). Based on the time-course experiment, we found that the inhibitory effect of PLM on adipogenesis was mainly involved in the early stage of adipogenesis. Studying these differential effects could uncover new mechanisms for regulating adipogenesis and new chemicals for treating obesity.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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