Validation of analytical methods for newly regulated veterinary drug residues in livestock and fishery products with maximum residue limits in Republic of Korea.

Autor: Park D; Ministry of Food and Drug Safety (MFDS), Pesticides & Veterinary Drug Residues Division, Cheongju-si, 28159, Republic of Korea., Han SB; College of Pharmacy, Chung Ang University, Seoul 06974, Republic of Korea., Shin HC; Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Republic of Korea., Choi YS; College of Pharmacy, Dankook University, Cheonan 31116, Republic of Korea., Kim YR; Ministry of Food and Drug Safety (MFDS), Pesticides & Veterinary Drug Residues Division, Cheongju-si, 28159, Republic of Korea., Kim JY; Ministry of Food and Drug Safety (MFDS), Pesticides & Veterinary Drug Residues Division, Cheongju-si, 28159, Republic of Korea. Electronic address: jykim98@korea.kr., Jang GH; Ministry of Food and Drug Safety (MFDS), Pesticides & Veterinary Drug Residues Division, Cheongju-si, 28159, Republic of Korea., Eom M; Ministry of Food and Drug Safety (MFDS), Pesticides & Veterinary Drug Residues Division, Cheongju-si, 28159, Republic of Korea.
Jazyk: angličtina
Zdroj: Food chemistry [Food Chem] 2024 Dec 01; Vol. 460 (Pt 3), pp. 140705. Date of Electronic Publication: 2024 Jul 31.
DOI: 10.1016/j.foodchem.2024.140705
Abstrakt: Veterinary drugs play a crucial role in the treatment of various animal diseases. However, their residues, stemming from issues, such as withdrawal period lapses, overuse, or abuse, can jeopardize food safety and human health. This study addresses recent regulations in Korea concerning specific veterinary drugs (anacolin, ephedrine, menichlopholan, piperonyl butoxide, and etisazole HCl) and their ongoing discussions. This study aimed to validate two pre-developed methods for quantifying residues in livestock and fishery products using QuEChERS and liquid chromatography-tandem mass spectrometry. Both methods exhibited excellent linearity, recoveries (70.3-119%), and coefficient of variations (1.3-28%), along with low limits of detection and quantification (0.3-4 ng/g and 1-12 ng/g). This study is significant for its contribution to the detection of veterinary drugs in livestock and fishery products, given the limited research available on the methods for analyzing these substances.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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