Stage-dependent phosphoproteome remodeling of Parkinson's disease blood cells.

Autor: Massacci G; Department of Biology, University of Rome Tor Vergata, Rome, Italy., Venafra V; PhD Program in Cellular and Molecular Biology, Department of Biology, University of Rome Tor Vergata, Rome, Italy., Zwiebel M; Department Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany., Wahle M; Department Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany., Cerroni R; Neurology Unit - Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy., Bissacco J; Neurology Unit - Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy., Perfetto L; Department of Biology and Biotechnologies 'Charles Darwin', University of Rome La Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy., Michienzi V; Neurology Unit - Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy., Stefani A; Neurology Unit - Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy., Mercuri NB; Neurology Unit - Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy., Schirinzi T; Neurology Unit - Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy. Electronic address: tommaso.schirinzi@uniroma2.it., Sacco F; Department of Biology, University of Rome Tor Vergata, Rome, Italy; Telethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Naples, Italy.
Jazyk: angličtina
Zdroj: Neurobiology of disease [Neurobiol Dis] 2024 Oct 01; Vol. 200, pp. 106622. Date of Electronic Publication: 2024 Aug 02.
DOI: 10.1016/j.nbd.2024.106622
Abstrakt: The complexity and heterogeneity of PD necessitate advanced diagnostic and prognostic tools to elucidate its molecular mechanisms accurately. In this study, we addressed this challenge by conducting a pilot phospho-proteomic analysis of peripheral blood mononuclear cells (PBMCs) from idiopathic PD patients at varying disease stages to delineate the functional alterations occurring in these cells throughout the disease course and identify key molecules and pathways contributing to PD progression. By integrating clinical data with phospho-proteomic profiles across various PD stages, we identify potential stage-specific molecular signatures indicative of disease progression. This integrative approach allows for the discernment of distinct disease states and enhances our understanding of PD heterogeneity.
Competing Interests: Declaration of competing interest Nothing to report.
(Copyright © 2024. Published by Elsevier Inc.)
Databáze: MEDLINE
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