Modulation of energetic and lipid pathways by curcumin as a potential chemopreventive strategy in human prostate cancer cells.

Autor: Pellegrino M; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036, Rende, Italy. Electronic address: michele.pellegrino@unical.it., Occhiuzzi MA; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036, Rende, Italy. Electronic address: mariaantonietta.occhiuzzi@unical.it., Grande F; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036, Rende, Italy. Electronic address: fedora.grande@unical.it., Pagani IS; Cancer Program, Precision Medicine Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA 5000, Australia. Electronic address: Ilaria.Pagani@sahmri.com., Aquaro S; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036, Rende, Italy. Electronic address: stefano.aquaro@unical.it., Tucci P; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036, Rende, Italy. Electronic address: paola.tucci@unical.it.
Jazyk: angličtina
Zdroj: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2024 Nov 26; Vol. 735, pp. 150477. Date of Electronic Publication: 2024 Jul 30.
DOI: 10.1016/j.bbrc.2024.150477
Abstrakt: In Western industrialized countries, prostate cancer (PCa) is the second most common malignant disease and prevalent cause of death for men. Epidemiological studies have shown that curcumin (CUR) either prevents PCa initiation or delays its progression to a more aggressive and treatment-refractory form, thus reducing related mortality. Our previous studies have proven the anticancer, antioxidant, and anti-inflammatory properties of CUR on PCa cells. However, there are few reports of the effect of CUR on energy and lipid pathways in PCa. Herein, we show that CUR can modulate the two metabolic energy pathways, increasing glycolytic reserve and reducing oxidative phosphorylation. Moreover, through the regulation of key enzymes and proteins, CUR affected the lipid pathway in PC-3 to a greater extent compared to the healthy PNT-2 cells. According to molecular docking investigations, the CUR activity in PCa may be mediated by the direct binding to the pyruvate dehydrogenase (PDHA1) enzyme, which is essential for regulating the appropriate mitochondrial activity. Taken together, our results shed light on the mechanism of action of CUR in the PCa cell metabolism and provide evidence of its potential value as an anticancer metabolic modulator, paving opportunities for novel therapeutic strategies.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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