5-Aminolaevulinic acid-based photodynamic therapy suppresses lipid secretion by inducing mitochondrial stress and oxidative damage in sebocytes and ameliorates ear acne in mice.

Autor: Jiang S; Department of Dermatology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China., Dong B; Department of Dermatology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China., Peng X; Department of Dermatology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China., Chen Y; Department of Dermatology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China. Electronic address: chenyan0101989@126.com., Mao H; Department of Dermatology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China. Electronic address: drmaohu@foxmail.com.
Jazyk: angličtina
Zdroj: International immunopharmacology [Int Immunopharmacol] 2024 Oct 25; Vol. 140, pp. 112795. Date of Electronic Publication: 2024 Aug 03.
DOI: 10.1016/j.intimp.2024.112795
Abstrakt: Acne is a chronic inflammatory skin disease with wide-ranging effects, involving factors such as Propionibacterium acnes (P. acnes) infection and sebum hypersecretion. Current acne treatments are challenged by drug resistance. 5-aminolaevulinic acid (ALA) -based photodynamic therapy (PDT) has been widely used in the clinical treatment of acne, however, the mechanism of its action remains to be elucidated. In this study, by constructing a mice ears model of P. acnes infection, we found that ALA-PDT inhibited the proliferation of P. acnes in vivo and in vitro, significantly ameliorated ear swelling, and blocked the chronic inflammatory process. In vitro, ALA-PDT inhibited lipid secretion and regulated the expression of lipid synthesis and metabolism-related genes in SZ95 cells. Further, we found that ALA-PDT led to DNA damage and apoptosis in SZ95 cells by inducing mitochondrial stress and oxidative stress. Altogether, our study demonstrated the great advantages of ALA-PDT for the treatment of acne and revealed that the mechanism may be related to the blockade of chronic inflammation and the suppression of lipid secretion by ALA-PDT.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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