Evaluation of different heterologous-homologous vaccine regimens against challenge with GI-23 lineage infectious bronchitis virus.

Autor: Houta MH; Poultry Diseases Department, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, 62511, Egypt. Electronic address: drhouta92@gmail.com., Hassan KE; Poultry Diseases Department, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, 62511, Egypt. Electronic address: kareem_eid@yahoo.com., Kilany WH; Reference Laboratory for Veterinary Quality Control on Poultry Production (RLQP), Animal Health Research Institute, Dokki, P.O. Box 264, Giza, 12618, Egypt. Electronic address: Walidhamdy78@yahoo.com., Shany SAS; Poultry Diseases Department, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, 62511, Egypt. Electronic address: salama.shany@vet.bsu.edu.eg., El-Sawah AA; Poultry Diseases Department, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, 62511, Egypt. Electronic address: azzasawah@yahoo.com., ElKady MF; Poultry Diseases Department, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, 62511, Egypt. Electronic address: mfelkady@vet.bsu.edu.eg., Abdel-Moneim AS; Microbiology Department, College of Medicine, Taif University, Al-Taif, 21974, Saudi Arabia. Electronic address: asa@tu.edu.sa., Ali A; Poultry Diseases Department, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, 62511, Egypt. Electronic address: ahmed.ali1@vet.bsu.edu.eg.
Jazyk: angličtina
Zdroj: Virology [Virology] 2024 Oct; Vol. 598, pp. 110193. Date of Electronic Publication: 2024 Jul 31.
DOI: 10.1016/j.virol.2024.110193
Abstrakt: This study assesses different IBV vaccination regimens in broiler chickens using commercially available live attenuated GI-23 (Egyptian-VAR2) and GI-1 (H120) vaccines. Vaccines were administered at 1, 14 days of age, or both. The ciliostasis test, following wild-type VAR2 challenge at 28 days of age, indicated that classic H120+VAR2 at one day old followed by the VAR2 vaccine at 14 days of age provided the highest level of protection (89.58%). Similarly, administering VAR2 at 1 day of age and classic H120 at 14 days of age demonstrated substantial protection (85.42%). Conversely, administering only classic H120 and VAR2 at one day old resulted in the lowest protection level (54.17%). Tracheal virus shedding quantification and assessment of trachea and kidney degenerative changes were significantly lower in vaccinated groups compared to the unvaccinated-challenged group. In conclusion, a carefully planned vaccination regimen based on homologous vaccination offers the most effective clinical protection in broiler chickens.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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