A Consensus Statement on the Administration of Systemic Bevacizumab in Patients with Recurrent Respiratory Papillomatosis.

Autor: Best SR; Department of Otolaryngology - Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, U.S.A., Bock JM; Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin, U.S.A., Fowler NB; Recurrent Respiratory Papillomatosis Foundation, Lawrenceville, New Jersey, U.S.A., Raabe EH; Division of Pediatric Oncology, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, U.S.A.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland, U.S.A., Klein AM; Department of Otolaryngology-Head and Neck Surgery, Emory Voice Center, Emory University School of Medicine, Atlanta, Georgia, U.S.A., Laetsch TW; Department of Pediatrics, Children's Hospital of Philadelphia/University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A., McClellan K; Recurrent Respiratory Papillomatosis Foundation, Lawrenceville, New Jersey, U.S.A., Rinkel RNPM; Department of Otorhinolaryngology/Head and Neck Surgery, Amsterdam UMC, Amsterdam, The Netherlands., Saba NF; Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, U.S.A., Sidell DR; Department of Otolaryngology, Head and Neck Surgery, Stanford Children's Health Aerodigestive and Airway Reconstruction Center and Stanford University, Stanford, California, U.S.A., Tansey JB; Recurrent Respiratory Papillomatosis Foundation, Lawrenceville, New Jersey, U.S.A., Tunkel DE; Department of Otolaryngology - Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, U.S.A., Young GD; Recurrent Respiratory Papillomatosis Foundation, Lawrenceville, New Jersey, U.S.A.; Department of Head and Neck Surgery, Miami Cancer Institute, Miami, Florida, U.S.A., Zur KB; Department of Otolaryngology, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A.
Jazyk: angličtina
Zdroj: The Laryngoscope [Laryngoscope] 2024 Dec; Vol. 134 (12), pp. 5041-5046. Date of Electronic Publication: 2024 Aug 03.
DOI: 10.1002/lary.31670
Abstrakt: Objective: To provide detailed guidance on the administration of systemic bevacizumab in patients with recurrent respiratory papillomatosis (RRP) based on a detailed review of the scientific literature and a consensus of experts with real-world clinical experience.
Methods: A bevacizumab consensus working group (N = 10) was composed of adult and pediatric otolaryngologists, adult and pediatric oncologists, and a representative from the RRP Foundation (RRPF), all with experience administering systemic bevacizumab in patients with RRP. After extensive review of the medical literature, a modified Delphi method-based survey series was utilized to establish consensus on the following key areas: clinical and patient characteristics ideal for treatment candidacy, patient perspective in treatment decisions, treatment access, initial dosing, monitoring, guidelines for tapering and discontinuation, and reintensifying therapy.
Results: Seventy-nine statements were identified across nine critical domains, and 45 reached consensus [clinical benefits of bevacizumab (3), patient and disease characteristics for treatment consideration (7), contraindications for treatment (3), shared decision-making (incorporating the patient perspective) (5), treatment access (3), initial dosing and administration (8), monitoring (7), tapering and discontinuation (6), and reintensification (3)].
Conclusion: This consensus statement provides the necessary guidance for clinicians to initiate systemic administration of bevacizumab and represents a potential paradigm shift toward nonsurgical treatment options for patients with RRP.
Level of Evidence: 5 Laryngoscope, 134:5041-5046, 2024.
(© 2024 The American Laryngological, Rhinological and Otological Society, Inc.)
Databáze: MEDLINE
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