The association between excess weight and COVID-19 outcomes: An umbrella review.

Autor: Matu J; Obesity Institute, School of Health, Leeds Beckett University, Leeds, UK., Griffiths A; Obesity Institute, School of Health, Leeds Beckett University, Leeds, UK., Shannon OM; Human Nutrition Research Centre, Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK., Jones A; Psychology, Liverpool John Moores University, Liverpool, UK., Day R; Obesity Institute, School of Health, Leeds Beckett University, Leeds, UK., Radley D; Obesity Institute, School of Sport, Leeds Beckett University, Leeds, UK., Feeley A; Office for Health Improvement and Disparities, London, UK., Mabbs L; Office for Health Improvement and Disparities, London, UK., Blackshaw J; Office for Health Improvement and Disparities, London, UK., Sattar N; School of Cardiovascular and Metabolic Health, British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK., Ells L; Obesity Institute, School of Health, Leeds Beckett University, Leeds, UK.
Jazyk: angličtina
Zdroj: Obesity reviews : an official journal of the International Association for the Study of Obesity [Obes Rev] 2024 Oct; Vol. 25 (10), pp. e13803. Date of Electronic Publication: 2024 Aug 03.
DOI: 10.1111/obr.13803
Abstrakt: This umbrella review assessed the association between excess weight and COVID-19 outcomes. MEDLINE, PsycINFO, and CINAHL were systematically searched for reviews that assessed the association between excess weight and COVID-19 outcomes. A second-order meta-analysis was conducted on the available data for intensive care unit admission, invasive mechanical ventilation administration, disease severity, hospitalization, and mortality. The quality of included reviews was assessed using the AMSTAR-2 appraisal tool. In total, 52 systematic reviews were included, 49 of which included meta-analyses. The risk of severe outcomes (OR = 1.86; 95% CI: 1.70 to 2.05), intensive care unit admission (OR = 1.58; 95% CI: 1.45 to 1.72), invasive mechanical ventilation administration (OR = 1.70; 95% CI: 1.57 to 1.83), hospitalization (OR = 1.82; 95% CI: 1.61 to 2.05), and mortality (OR = 1.35; 95% CI: 1.24 to 1.48) following COVID-19 infection was significantly higher in individuals living with excess weight compared with those with a healthy weight. There was limited evidence available in the included reviews regarding the influence of moderating factors such as ethnicity, and the majority of included reviews were of poor quality. Obesity appears to represent an important modifiable pre-infection risk factor for severe COVID-19 outcomes, including death.
(© 2024 The Author(s). Obesity Reviews published by John Wiley & Sons Ltd on behalf of World Obesity Federation.)
Databáze: MEDLINE
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