New concept in selecting blue dye injection site effect on clinical outcome of early-stage breast cancer patients: a retrospective cohort.

Autor: Bongkodmas P; Department of Surgery, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Vacharathit V; Department of Surgery, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Lerttiendamrong B; Department of Surgery, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Manasnayakorn S; Department of Surgery, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Tantiphlachiva K; Department of Surgery, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Vongwattanakit P; Department of Surgery, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Treeratanapun N; Department of Surgery, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Vongsaisuwon M; Department of Surgery, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. mawin.v@chula.ac.th.
Jazyk: angličtina
Zdroj: World journal of surgical oncology [World J Surg Oncol] 2024 Aug 03; Vol. 22 (1), pp. 207. Date of Electronic Publication: 2024 Aug 03.
DOI: 10.1186/s12957-024-03493-4
Abstrakt: Background: Clinico-anatomical review and pilot studies demonstrated that intraparenchymal injection at any site, even those not containing the index lesion, or periareolar injections should provide concordant outcomes to peritumoral injections.
Method: This was a single-center retrospective cohort at King Chulalongkorn Memorial Hospital. The electronic medical records of patients were characterized into conventional and new injection concept groups. The inclusion criteria were patients who had either a mastectomy or BCS along with SLNB. We excluded patients who underwent ALND, received neoadjuvant therapy, or had non-invasive breast cancer. The primary outcome was the 5-year rate of breast cancer regional recurrence. Additionally, we reported on the re-operation rate, disease-free period, distant disease-free period, mortality rate, and recurrence rates both locoregional and systemic. Recurrences were identified through clinical assessments and imaging.
Surgical Technique: 3 ml of 1%isosulfan blue dye was injected, with the injection site varying according to the specific concept being applied. In cases of SSM and NSM following the new concept, the blue dye was injected at non-periareolar and non-peritumoral sites. After the injection, a 10-minute interval was observed without massaging the injection site. Following this interval, an incision was made to access the SLNs, which were subsequently identified, excised, and sent for either frozen section analysis or permanent section examination.
Result: There were no significant differences in DFS, DDFS or BCSS between the two groups (p = 0.832, 0.712, 0.157). Although the re-operation rate in the NI group was approximately half that of the CI group, this difference was not statistically significant (p = 0.355).
Conclusion: Our study suggests that tailoring isosulfan blue dye injection site based on operation type rather than tumor location is safe and effective approach for SLN localization in early-stage breast cancer. However, this study has limitations, including being a single-center study with low recurrence and death cases. Future studies should aim to increase the sample size and follow-up period.
(© 2024. The Author(s).)
Databáze: MEDLINE
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