Transdermal pilocarpine on the skin over salivary glands to increase salivation: an in vivo study.

Autor: Ishida N; Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Science, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa, 920-1192, Japan. naishida@p.kanazawa-u.ac.jp., Katsura A; Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Science, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa, 920-1192, Japan., Takagaki K; Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Science, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa, 920-1192, Japan., Arakawa H; Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Science, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa, 920-1192, Japan., Shimada T; Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Science, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa, 920-1192, Japan.; Department of Clinical Pharmacokinetics, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan.; Department of Hospital Pharmacy, University Hospital, Kanazawa University, 13-1 Takara- machi, Kanazawa, Ishikawa, 920-8641, Japan., Mizuno S; Department of Clinical Pharmacokinetics, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan., Sai Y; Department of Clinical Pharmacokinetics, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan.; Department of Hospital Pharmacy, University Hospital, Kanazawa University, 13-1 Takara- machi, Kanazawa, Ishikawa, 920-8641, Japan., Kato Y; Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Science, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa, 920-1192, Japan., Nakamura H; Department of Oral and Maxillofacial Surgery, Ryukyu University Graduate School of Medical Science, 207 Uehara, Nishihara, Nakagami, 903-0215, Okinawa, Japan., Suga Y; Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Science, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa, 920-1192, Japan., Matsushita R; Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Science, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa, 920-1192, Japan.
Jazyk: angličtina
Zdroj: BMC oral health [BMC Oral Health] 2024 Aug 02; Vol. 24 (1), pp. 881. Date of Electronic Publication: 2024 Aug 02.
DOI: 10.1186/s12903-024-04667-y
Abstrakt: Background: Hyposalivation is treated using oral cholinergic drugs; however, systemic side effects occasionally lead to discontinuation of treatment. We aimed to investigate the effects of transdermal pilocarpine on the salivary gland skin on saliva secretion and safety in rats.
Methods: Pilocarpine was administered to rats orally (0.5 mg/kg) or topically on the salivary gland skin (5 mg/body). Saliva volume, the number of sweat dots, and fecal weight were measured along with pilocarpine concentration in plasma and submandibular gland tissues.
Results: Saliva volume significantly increased 0.5 h after oral administration and 0.5, 3, and 12 h after topical administration. Fecal weight and sweat dots increased significantly 1 h after oral administration; however, no changes were observed after topical application. The pilocarpine concentration in the submandibular gland tissues of the topical group was higher than that in the oral group at 0.5, 3, and 12 h of administration.
Conclusions: Pilocarpine application to salivary gland skin persistently increased salivary volume in rats without inducing sweating or diarrhea. Transdermal pilocarpine applied to the skin over the salivary glands may be an effective and safe treatment option for hyposalivation.
(© 2024. The Author(s).)
Databáze: MEDLINE
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