Exercise effects on brain health and learning from minutes to months: The brain EXTEND trial.

Autor: Voss MW; Department of Psychological and Brain Sciences, College of Liberal Arts and Sciences, The University of Iowa, USA; Iowa Neuroscience Institute, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA; Interdisciplinary Neuroscience Training Program, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA. Electronic address: michelle-voss@uiowa.edu., Oehler C; Department of Psychological and Brain Sciences, College of Liberal Arts and Sciences, The University of Iowa, USA., Daniels W; Department of Psychological and Brain Sciences, College of Liberal Arts and Sciences, The University of Iowa, USA., Sodoma M; Department of Psychological and Brain Sciences, College of Liberal Arts and Sciences, The University of Iowa, USA., Madero B; Department of Psychological and Brain Sciences, College of Liberal Arts and Sciences, The University of Iowa, USA., Kent J; Department of Psychological and Brain Sciences, College of Liberal Arts and Sciences, The University of Iowa, USA., Jain S; Department of Psychological and Brain Sciences, College of Liberal Arts and Sciences, The University of Iowa, USA., Jung M; Department of Psychological and Brain Sciences, College of Liberal Arts and Sciences, The University of Iowa, USA., Nuckols VR; Department of Health and Human Physiology, College of Liberal Arts and Sciences, The University of Iowa, USA., DuBose LE; Department of Health and Human Physiology, College of Liberal Arts and Sciences, The University of Iowa, USA., Davis KG; Department of Health and Human Physiology, College of Liberal Arts and Sciences, The University of Iowa, USA., O'Deen A; Department of Psychological and Brain Sciences, College of Liberal Arts and Sciences, The University of Iowa, USA., Hamilton C; Department of Psychological and Brain Sciences, College of Liberal Arts and Sciences, The University of Iowa, USA., Baller K; Department of Psychological and Brain Sciences, College of Liberal Arts and Sciences, The University of Iowa, USA., Springer J; Department of Psychological and Brain Sciences, College of Liberal Arts and Sciences, The University of Iowa, USA; Department of Health and Human Physiology, College of Liberal Arts and Sciences, The University of Iowa, USA., Rivera-Dompenciel A; Department of Psychological and Brain Sciences, College of Liberal Arts and Sciences, The University of Iowa, USA; Iowa Neuroscience Institute, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA; Interdisciplinary Neuroscience Training Program, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA., Pipoly M; Department of Psychological and Brain Sciences, College of Liberal Arts and Sciences, The University of Iowa, USA; Iowa Neuroscience Institute, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA; Interdisciplinary Neuroscience Training Program, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA., Muellerleile M; Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA., Nagarajan N; Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA., Bjarnason T; Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA., Harb N; Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA., Lin LC; Iowa Neuroscience Institute, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA; Department of Neuroscience and Pharmacology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA., Magnotta V; Department of Psychiatry, Carver College of Medicine, The University of Iowa, USA; Iowa Neuroscience Institute, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA; Interdisciplinary Neuroscience Training Program, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA., Hazeltine E; Department of Psychological and Brain Sciences, College of Liberal Arts and Sciences, The University of Iowa, USA; Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA., Long JD; Department of Psychiatry, Carver College of Medicine, The University of Iowa, USA; Department of Biostatistics, College of Public Health, The University of Iowa, USA., Pierce GL; Department of Health and Human Physiology, College of Liberal Arts and Sciences, The University of Iowa, USA; Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Jazyk: angličtina
Zdroj: Contemporary clinical trials [Contemp Clin Trials] 2024 Oct; Vol. 145, pp. 107647. Date of Electronic Publication: 2024 Jul 31.
DOI: 10.1016/j.cct.2024.107647
Abstrakt: Despite evidence that aerobic exercise benefits the aging brain, in particular the hippocampus and memory, controlled clinical trials have not comprehensively evaluated effects of aerobic exercise training on human memory in older adults. The central goal of this study was to determine chronic effects of moderate-to-vigorous intensity aerobic exercise on the hippocampus and memory in non-demented, inactive adults ages 55-80 years. We determine effects of aerobic exercise training with a 6-month randomized controlled trial (RCT) comparing 150 min/week of home-based, light intensity exercise with progressive moderate-to-vigorous intensity aerobic exercise. For the first time in a large trial, we examined temporal mechanisms by determining if individual differences in the rapid, immediate effects of moderate intensity exercise on hippocampal-cortical connectivity predict chronic training-related changes over months in connectivity and memory. We examined physiological mechanisms by testing the extent to which chronic training-related changes in cardiorespiratory fitness are a critical factor to memory benefits. The Exercise Effects on Brain Connectivity and Learning from Minutes to Months (Brain-EXTEND) trial is conceptually innovative with advanced measures of hippocampal-dependent learning and memory processes combined with novel capture of the physiological changes, genetic components, and molecular changes induced by aerobic exercise that change hippocampal-cortical connectivity. Given that hippocampal connectivity deteriorates with Alzheimer's and aerobic exercise may contribute to reduced risk of Alzheimer's, our results could lead to an understanding of the physiological mechanisms and moderators by which aerobic exercise reduces risk of this devastating and costly disease.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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