Inferior vena CAVA and lung ultraSound-guided therapy in acute heart failure: A randomized pilot study (CAVAL US-AHF study).

Autor: Burgos LM; Heart failure, pulmonary hypertension and heart transplant division, Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina. Electronic address: lburgos@icba.com.ar., Baro Vila RC; Heart failure, pulmonary hypertension and heart transplant division, Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina., Ballari FN; Heart failure, pulmonary hypertension and heart transplant division, Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina., Goyeneche A; Clinical cardiology department, Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina., Costabel JP; Clinical cardiology department, Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina., Muñoz F; Clinical cardiology department, Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina., Spaccavento A; Clinical cardiology department, Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina., Fasan MA; Clinical cardiology department, Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina., Suárez LL; Clinical cardiology department, Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina., Vivas M; Clinical cardiology department, Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina., Riznyk L; Clinical cardiology department, Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina., Ghibaudo S; Clinical cardiology department, Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina., Trivi M; Clinical cardiology department, Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina., Ronderos R; Clinical cardiology department, Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina., Botto F; Clinical cardiology department, Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina., Diez M; Heart failure, pulmonary hypertension and heart transplant division, Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina.
Jazyk: angličtina
Zdroj: American heart journal [Am Heart J] 2024 Nov; Vol. 277, pp. 47-57. Date of Electronic Publication: 2024 Jul 31.
DOI: 10.1016/j.ahj.2024.07.015
Abstrakt: Background: The optimal assessment of systemic and lung decongestion during acute heart failure is not clearly defined. We evaluated whether inferior vena cava (IVC) and pulmonary ultrasound (CAVAL US) guided therapy is superior to standard care in reducing subclinical congestion at discharge in patients with AHF.
Methods: CAVAL US-AHF was an investigator-initiated, single-center, single-blind, randomized controlled trial. A daily quantitative ultrasound protocol using the 8-zone method was used and treatment was adjusted according to an algorithm. The primary endpoint was the presence of more than 5 B-lines and/or an increase in IVC diameter and collapsibility at discharge. And secondary endpoint exploratory outcome was the composite of readmission for HF, unplanned visit for worsening HF or death at 90 days RESULTS: Sixty patients were randomized to CAVAL US (n = 30) or control (n = 30). The primary endpoint was achieved in 4 patients (13.3%) in the CAVAL US group and 20 patients (66.6%) in the control group (P < .001). A significant reduction in HF readmission, unplanned visit for worsening HF or death at 90 days was seen in the CAVAL US group (13.3% vs 36.7%; log rank P = .038). Other endpoints such as NT-proBNP reduction at discharge showed a nonstatistically significant reduction in the CAVAL US group (48% IQR 27-67 vs 37% -3-59; P = .09). Safety outcomes were similar in both groups.
Conclusion: IVC and lung ultrasound-guided therapy in AHF patients significantly reduced subclinical congestion at discharge. CAVAL US-AHF provides preliminary evidence for the potential use of a simple technique to guide decongestive therapy during hospitalization for AHF, which may reduce the composite outcome at 90 days.
Competing Interests: Declaration of competing interest None reported.
(Copyright © 2024. Published by Elsevier Inc.)
Databáze: MEDLINE
Externí odkaz: