Recommendations for Deprescribing of Medication in the Last Phase of Life: An International Delphi Study.

Autor: Elsten EECM; Department of Medical Oncology (E.E.C.M.E., I.E.P., E.C.T.G., C.C.D.V.D.R.), Erasmus Medical Center, Cancer Institute Rotterdam, Netherlands; Department of Public Health (E.E.C.M.E., A.V.D.H.), Erasmus Medical Center, University Medical Center Rotterdam, Netherlands., Pot IE; Department of Medical Oncology (E.E.C.M.E., I.E.P., E.C.T.G., C.C.D.V.D.R.), Erasmus Medical Center, Cancer Institute Rotterdam, Netherlands. Electronic address: i.pot@erasmusmc.nl., Geijteman ECT; Department of Medical Oncology (E.E.C.M.E., I.E.P., E.C.T.G., C.C.D.V.D.R.), Erasmus Medical Center, Cancer Institute Rotterdam, Netherlands., Hedman C; R & D Department (C.H.), Stockholms Sjukhem Foundation, Stockholm, Sweden; Department of Molecular Medicine and Surgery (C.H.), Karolinska Institutet, Stockholm, Sweden; Department of Clinical Sciences (C.H.), Lund University, Lund, Sweden; Institute for Palliative Care (C.H., C.J.F.), Lund University and Region Skåne, Lund, Sweden., van der Heide A; Department of Public Health (E.E.C.M.E., A.V.D.H.), Erasmus Medical Center, University Medical Center Rotterdam, Netherlands., van der Kuy PHM; Department of Hospital Pharmacy (H.V.D.K.), Erasmus Medical Center, Rotterdam, Netherlands., Fürst CJ; Institute for Palliative Care (C.H., C.J.F.), Lund University and Region Skåne, Lund, Sweden., Eychmüller S; University Center for Palliative Care (S.E.), University Hospital Inselspital Bern, Bern, Switzerland., van Zuylen L; Department of Medical Oncology (L.V.Z.), Amsterdam University Medical Center, Amsterdam, Netherlands., van der Rijt CCD; Department of Medical Oncology (E.E.C.M.E., I.E.P., E.C.T.G., C.C.D.V.D.R.), Erasmus Medical Center, Cancer Institute Rotterdam, Netherlands.
Jazyk: angličtina
Zdroj: Journal of pain and symptom management [J Pain Symptom Manage] 2024 Nov; Vol. 68 (5), pp. 443-455.e2. Date of Electronic Publication: 2024 Aug 02.
DOI: 10.1016/j.jpainsymman.2024.07.029
Abstrakt: Context: Medications may become inappropriate for patients in the last phase of life and may even compromise their quality of life.
Objective: To find consensus on recommendations regarding deprescribing of medications for adult patients with a life expectancy of six months or less.
Methods: Experts working in palliative care or other relevant disciplines were asked to participate in this international Delphi study. Existing tools for deprescribing of medication in the last phase of life were integrated in a list of 42 recommendations regarding potential deprescription of various medication types. In two Delphi rounds, experts were asked to rate their agreement with each recommendation on a 5-point Likert-scale (strongly agree-strongly disagree). Recommendations were accepted, if at least 70% of the experts (strongly) agreed, the interquartile range (IQR) was one or less, and less than 10% strongly disagreed.
Results: About 47 experts from 10 countries participated (response rate 53%). In most cases (76%), consensus was reached on deprescribing recommendations for patients with a life expectancy of six months or less. The highest level of consensus was reached for recommendations on the deprescription of diuretics in case of decreasing fluid intake or increasing fluid loss, lipid modifying agents if prescribed for primary prevention, and vitamin K antagonists and direct oral anticoagulants in case of high bleeding risk.
Conclusion: A high level of consensus was reached on recommendations on potential deprescription of several medications for patients with a life expectancy of six months or less.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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