Can Two-Dimensional Correlation Spectroscopy (2D-COS) Indicate Biocompatible Material?

Autor:	Wesełucha-Birczyńska A; Faculty of Chemistry, Jagiellonian University, Kraków, Poland., Długoń E; Faculty of Material Science and Ceramics, AGH University of Science and Technology, Kraków, Poland., Morajka K; Faculty of Chemistry, Jagiellonian University, Kraków, Poland., Błażewicz M; Faculty of Material Science and Ceramics, AGH University of Science and Technology, Kraków, Poland.
Jazyk:	angličtina
Zdroj:	Applied spectroscopy [Appl Spectrosc] 2024 Aug 12, pp. 37028241268223. Date of Electronic Publication: 2024 Aug 12.
DOI:	10.1177/00037028241268223
Abstrakt:	Carbon nanofibers are a new type of carbon materials. One of the methods of obtaining them is the carbonization of a polymer precursor. They are attractive in many areas, including medicine, due to the possibility of modifying their properties in a wide range. For example, the conditions of the carbonization process result in the creation of materials with designed structures and surface parameters. In the current work, the nanoprecursor was polyacrylonitrile (PAN) fibers. Two types of carbon fibers obtained by carbonization of the PAN precursor at 1000 °C were tested. The first electrospun carbon nanofibers (ESCNFs) were cytotoxic, while the second ESCNF-f were biocompatible after functionalization. The parameters obtained from Raman tests did not clearly discriminate between the tested materials. Multiwavelength Raman studies, analyzed using the two-dimensional correlation spectroscopy (2D-COS), treating the laser energy as an external disturbance, showed a difference between both fibrous structures. 2D-COS indicates that structures resembling graphite systems, devoid of disordered carbon forms, are nontoxic. Competing Interests: Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
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