Recruited atypical Ly6G + macrophages license alveolar regeneration after lung injury.

Autor: Ruscitti C; Laboratory of Immunophysiology, GIGA Institute, University of Liège, Liège, Belgium.; Faculty of Veterinary Medicine, University of Liège, Liège, Belgium., Abinet J; Laboratory of Immunophysiology, GIGA Institute, University of Liège, Liège, Belgium.; Faculty of Veterinary Medicine, University of Liège, Liège, Belgium., Maréchal P; Laboratory of Immunophysiology, GIGA Institute, University of Liège, Liège, Belgium.; Faculty of Veterinary Medicine, University of Liège, Liège, Belgium., Meunier M; Laboratory of Immunophysiology, GIGA Institute, University of Liège, Liège, Belgium.; Faculty of Veterinary Medicine, University of Liège, Liège, Belgium., de Meeûs C; Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.; Department of Pathology, FARAH Institute, University of Liège, Liège, Belgium., Vanneste D; Laboratory of Immunophysiology, GIGA Institute, University of Liège, Liège, Belgium.; Faculty of Veterinary Medicine, University of Liège, Liège, Belgium., Janssen P; Laboratory of Immunophysiology, GIGA Institute, University of Liège, Liège, Belgium.; Faculty of Veterinary Medicine, University of Liège, Liège, Belgium., Dourcy M; Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.; Laboratory of Immunology-Vaccinology, FARAH Institute, University of Liège, Liège, Belgium., Thiry M; Laboratory of Cellular and Tissular Biology, GIGA Institute, University of Liège, Liège, Belgium., Bureau F; Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.; Laboratory of Cellular and Molecular Immunology, GIGA Institute, University of Liège, Liège, Belgium., Schneider C; Institute of Physiology, University of Zurich, Zurich, Switzerland., Machiels B; Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.; Laboratory of Immunology-Vaccinology, FARAH Institute, University of Liège, Liège, Belgium., Hidalgo A; Area of Cell & Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.; Vascular Biology and Therapeutics Program and Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Ginhoux F; Shanghai Institute of Immunology, Shanghai JiaoTong University School of Medicine, Shanghai, China.; Inserm U1015, Gustave Roussy, Bâtiment de Médecine Moléculaire, Villejuif, France.; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Translational Immunology Institute, SingHealth Duke-NUS Academic Medical Centre, Singapore, Singapore., Dewals BG; Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.; Laboratory of Immunology-Vaccinology, FARAH Institute, University of Liège, Liège, Belgium., Guiot J; Laboratory of Pneumology, GIGA Institute, University of Liège, Liège, Belgium.; Department of Respiratory Medicine, CHU University Hospital, Liège, Belgium., Schleich F; Laboratory of Pneumology, GIGA Institute, University of Liège, Liège, Belgium.; Department of Respiratory Medicine, CHU University Hospital, Liège, Belgium., Garigliany MM; Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.; Department of Pathology, FARAH Institute, University of Liège, Liège, Belgium., Bellahcène A; Metastasis Research Laboratory, GIGA Institute, University of Liège, Liège, Belgium., Radermecker C; Laboratory of Immunophysiology, GIGA Institute, University of Liège, Liège, Belgium.; Faculty of Veterinary Medicine, University of Liège, Liège, Belgium., Marichal T; Laboratory of Immunophysiology, GIGA Institute, University of Liège, Liège, Belgium.; Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.; Walloon Excellence in Life Sciences and Biotechnology (WELBIO) Department, WEL Research Institute, Wavre, Belgium.
Jazyk: angličtina
Zdroj: Science immunology [Sci Immunol] 2024 Aug 02; Vol. 9 (98), pp. eado1227. Date of Electronic Publication: 2024 Aug 02.
DOI: 10.1126/sciimmunol.ado1227
Abstrakt: The lung is constantly exposed to airborne pathogens and particles that can cause alveolar damage. Hence, appropriate repair responses are essential for gas exchange and life. Here, we deciphered the spatiotemporal trajectory and function of an atypical population of macrophages after lung injury. Post-influenza A virus (IAV) infection, short-lived monocyte-derived Ly6G-expressing macrophages (Ly6G + Macs) were recruited to the alveoli of lung perilesional areas. Ly6G + Macs engulfed immune cells, exhibited a high metabolic potential, and clustered with alveolar type 2 epithelial cells (AT2s) in zones of active epithelial regeneration. Ly6G + Macs were partially dependent on granulocyte-macrophage colony-stimulating factor and interleukin-4 receptor signaling and were essential for AT2-dependent alveolar regeneration. Similar macrophages were recruited in other models of injury and in the airspaces of lungs from patients with suspected pneumonia. This study identifies perilesional alveolar Ly6G + Macs as a spatially restricted, short-lived macrophage subset promoting epithelial regeneration postinjury, thus representing an attractive therapeutic target for treating lung damage.
Databáze: MEDLINE