Use of Adjuvant Compositions Based on Squalene Ensures Induction of Neutralizing Antibodies against SARS-CoV-2.

Autor: Volosnikova EA; State Research Center of Virology and Biotechnology 'VECTOR', Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Koltsovo, Novosibirsk region, Russia. volosnikova_ea@vector.nsc.ru., Volkova NV; State Research Center of Virology and Biotechnology 'VECTOR', Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Koltsovo, Novosibirsk region, Russia., Ermolaev VV; State Research Center of Virology and Biotechnology 'VECTOR', Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Koltsovo, Novosibirsk region, Russia., Borgoyakova MB; State Research Center of Virology and Biotechnology 'VECTOR', Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Koltsovo, Novosibirsk region, Russia., Nesmeyanova VS; State Research Center of Virology and Biotechnology 'VECTOR', Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Koltsovo, Novosibirsk region, Russia., Zaykovskaya AV; State Research Center of Virology and Biotechnology 'VECTOR', Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Koltsovo, Novosibirsk region, Russia., Pyankov OV; State Research Center of Virology and Biotechnology 'VECTOR', Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Koltsovo, Novosibirsk region, Russia., Zaitsev BN; State Research Center of Virology and Biotechnology 'VECTOR', Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Koltsovo, Novosibirsk region, Russia., Belenkaya SV; State Research Center of Virology and Biotechnology 'VECTOR', Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Koltsovo, Novosibirsk region, Russia., Isaeva AA; State Research Center of Virology and Biotechnology 'VECTOR', Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Koltsovo, Novosibirsk region, Russia., Shcherbakov DN; State Research Center of Virology and Biotechnology 'VECTOR', Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Koltsovo, Novosibirsk region, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2024 Jun; Vol. 177 (2), pp. 221-224. Date of Electronic Publication: 2024 Aug 02.
DOI: 10.1007/s10517-024-06160-6
Abstrakt: Squalene-based adjuvant compositions that can provide effective induction of specific humoral immune response have been developed. Recombinant receptor-binding domain (RBD) of surface S-protein of SARS-CoV-2 was used to evaluate the properties of the composition. Immunization of mice with the developed squalene-based compositions in combination with RBD allows obtaining high titers of specific antibodies: from 10 5 to 2×10 6 . The blood sera from immunized mice exhibit neutralizing activity against SARS-CoV-2 Delta variant (B.1.617.2) with a titer up to 1:2000.
(© 2024. Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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