Impact of Experimental Tuberculosis on Fertility of Female BALB/c Mice.

Autor: Kayukova SI; Central Research Institute of Tuberculosis, Moscow, Russia. kajukovalnp@gmail.com., Karpina NL; Central Research Institute of Tuberculosis, Moscow, Russia., Ulyumdzhieva VA; Central Research Institute of Tuberculosis, Moscow, Russia., Semenova LA; Central Research Institute of Tuberculosis, Moscow, Russia., Donnikov AE; National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V. I. Kulakov, Ministry of Health of the Russian Federation, Moscow, Russia., Bocharova IV; Central Research Institute of Tuberculosis, Moscow, Russia., Nikonenko BV; Central Research Institute of Tuberculosis, Moscow, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2024 Jun; Vol. 177 (2), pp. 256-260. Date of Electronic Publication: 2024 Aug 02.
DOI: 10.1007/s10517-024-06168-y
Abstrakt: The study revealed no effects of pregnancy and childbirth on the course of tuberculosis in female BALB/c mice after aerosol infection with Mycobacterium tuberculosis. However, we demonstrated a negative effect of tuberculosis infection on the fertility of infected females, which manifested in a longer period from mating to pregnancy and in a smaller litter size. Impaired reproductive function in response to the effect of the systemic infectious process was accompanied by the development of immunosuppression confirmed by an immunological test (delayed-type hypersensitivity to tuberculin) and the formation of genital tract dysbiosis during pregnancy and postpartum period.
(© 2024. Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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