Sex differences and predictors of anti-osteoporosis medication use in the 12 months after hip fracture surgery in adults 65 or older.

Autor: Kirk JM; Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Howard Hall, Suite 200, 660 W. Redwood St., Baltimore, MD, 21201, USA. jenniferkirk.phd@gmail.com.; Social Science Research Institute, Population Research Institute, Pennsylvania State University, University Park, PA, USA. jenniferkirk.phd@gmail.com., Rathbun AM; Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Howard Hall, Suite 200, 660 W. Redwood St., Baltimore, MD, 21201, USA.; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Gruber-Baldini AL; Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Howard Hall, Suite 200, 660 W. Redwood St., Baltimore, MD, 21201, USA.; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Hochberg MC; Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Howard Hall, Suite 200, 660 W. Redwood St., Baltimore, MD, 21201, USA.; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Magaziner J; Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Howard Hall, Suite 200, 660 W. Redwood St., Baltimore, MD, 21201, USA.; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Shardell MD; Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Howard Hall, Suite 200, 660 W. Redwood St., Baltimore, MD, 21201, USA., Orwig D; Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Howard Hall, Suite 200, 660 W. Redwood St., Baltimore, MD, 21201, USA.; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Jazyk: angličtina
Zdroj: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA [Osteoporos Int] 2024 Nov; Vol. 35 (11), pp. 1943-1950. Date of Electronic Publication: 2024 Aug 02.
DOI: 10.1007/s00198-024-07211-4
Abstrakt: Purpose: This study evaluates sex differences and predictors of anti-osteoporosis medication (AOM) use following a hip fracture, with a focus on older men who exhibit higher mortality rates post-fracture compared to women over the age of 65.
Methods: Participants included 151 men and 161 women aged 65 and older with hip fractures. The outcome, AOM use, was assessed at baseline (≤ 22 days of hospitalization) and at 2, 6, and 12 months post-hip fracture. Generalized estimating equations (GEE) modeled sex differences and predictors of AOM use during the year post-fracture in 255 participants with complete baseline data and ≥ 1 follow-up observation.
Results: Of the 312 participants, only 53 used AOM at baseline, and 35 initiated use during follow-up. In the unadjusted GEE model, AOM use was significantly less likely in men (OR = 0.42; 95% CI, 0.22-0.78) compared to women. For both men and women, baseline use of AOM was a significant predictor (OR = 28.3; 95% CI, 5.4-148.0 vs. 41.6; 95% CI, 14.0-123.0). The other significant predictors by sex were osteoporosis diagnosis (OR = 3.19; 95% CI, 1.16-8.77) and minimal alcohol use (OR = 3.26; 95% CI, 1.34-7.94) for women versus age (OR = 1.09; 95% CI, 1.01-1.18) for men.
Conclusion: In older adults with hip fractures, AOM use is low over the year post-fracture and men are less likely to report AOM use compared to women which has implications for important sex differences in predictors of use. Further research is needed to address overall disparities and sex differences in AOM use.
(© 2024. International Osteoporosis Foundation and Bone Health and Osteoporosis Foundation.)
Databáze: MEDLINE
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