Resistance exercise breaks during prolonged sitting augment the blood flow response to a subsequent oral glucose load in sedentary adults.

Autor: Rogers EM; Department of Health and Human Physiology, The University of Iowa, Iowa City, Iowa, USA.; Department of Kinesiology, The University of Wisconsin, Madison, Wisconsin, USA., Banks NF; Department of Health and Human Physiology, The University of Iowa, Iowa City, Iowa, USA.; Department of Kinesiology, The University of Wisconsin, Madison, Wisconsin, USA., Trachta ER; Department of Health and Human Physiology, The University of Iowa, Iowa City, Iowa, USA., Wolf MS; Department of Health and Human Physiology, The University of Iowa, Iowa City, Iowa, USA., Berry AC; Department of Health and Human Physiology, The University of Iowa, Iowa City, Iowa, USA., Stanhewicz AE; Department of Health and Human Physiology, The University of Iowa, Iowa City, Iowa, USA., Carr LJ; Department of Health and Human Physiology, The University of Iowa, Iowa City, Iowa, USA.; Fraternal Order of Eagles Diabetes Research Center, The University of Iowa, Iowa City, USA., Gibbs BB; Department of Epidemiology and Biostatistics, West Virginia University School of Public Health, Morgantown, West Virginia, USA., Jenkins NDM; Department of Health and Human Physiology, The University of Iowa, Iowa City, Iowa, USA.; Abboud Cardiovascular Research Center, The University of Iowa, Iowa City, Iowa, USA.; Fraternal Order of Eagles Diabetes Research Center, The University of Iowa, Iowa City, USA.
Jazyk: angličtina
Zdroj: Experimental physiology [Exp Physiol] 2024 Aug 02. Date of Electronic Publication: 2024 Aug 02.
DOI: 10.1113/EP091535
Abstrakt: Sitting-induced impairments in postprandial blood flow are an important link between sedentary behaviour and cardiometabolic disease risk. The objective of this work was to examine the effects of resistance exercise breaks (REB) performed every 30 min during an otherwise sedentary 3-h period on the vasodilatory response to a subsequent oral glucose load in sedentary adults. Twenty-four sedentary adults (27 ± 7 years, 16 females) completed two conditions. Fasting blood glucose, insulin, popliteal artery blood flow (PABF) and gastrocnemius perfusion were measured immediately before standardized breakfast consumption. After breakfast, the 3-h REB or uninterrupted (SIT) intervention period commenced. Participants sat at a workstation, and popliteal artery shear rate (PASR) was measured 60 and 120 min into this period. In the REB condition, participants performed a 3-min REB (3 × [20 s squats, 20 s high knees, 20 s calf raises]) every 30 min. Following the intervention period, baseline measurements were repeated. Participants then consumed a 75 g glucose beverage, and PABF and perfusion were measured every 30-60 min for the following 120 min. Relative to SIT, REB increased PASR at 60 min (+31.4 ± 9.2/s, P = 0.037) and 120 min (+37.4 ± 10.2/s, P = 0.019) into the intervention period. Insulin and glucose increased (P < 0.001) in response to glucose consumption, with no differences between conditions (P ≥ 0.299). In response to the glucose load, perfusion (1.57 vs. 1.11 mL/100 mL/min, P = 0.023) and PABF (+45.3 ± 11.8 mL/min, P = 0.001) were greater after REB versus SIT. Performing 3-min REB every 30 min during an otherwise sedentary 3-h period augmented leg blood flow responses to an oral glucose load. HIGHLIGHTS: What is the central question of this study? Can 3-min resistance exercise breaks (REB) performed during an otherwise sedentary 3-h period augment the vasodilatory response to a subsequent oral glucose load in sedentary adults? What is the main finding and its importance? Performing 3-min REB, which included squats, high knees, and calf raises, every 30 min augmented lower limb blood flow responses to a subsequent oral glucose load compared to 3 h of uninterrupted sitting in sedentary adults. Sitting-induced impairment in postprandial vasodilatory function has been identified as a link between sedentary behaviour and cardiometabolic disease. Thus, the current study presents a potentially effective strategy to offset this risk.
(© 2024 The Author(s). Experimental Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society.)
Databáze: MEDLINE
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