Exploring Radiofrequency Ablation for T1 Papillary Thyroid Cancer in the United States: Mayo Clinic Experience.

Autor:	Rachmasari KN; Division of Endocrinology, Diabetes, and Nutrition, Mayo Clinic, Rochester, MN., Schmitz JJ; Department of Radiology, Mayo Clinic, Rochester, MN., Castro MR; Division of Endocrinology, Diabetes, and Nutrition, Mayo Clinic, Rochester, MN., Kurup AN; Department of Radiology, Mayo Clinic, Rochester, MN., Lee RA; Department of Radiology, Mayo Clinic, Rochester, MN., Stan MN; Division of Endocrinology, Diabetes, and Nutrition, Mayo Clinic, Rochester, MN. Electronic address: stan.marius@mayo.edu.
Jazyk:	angličtina
Zdroj:	Mayo Clinic proceedings [Mayo Clin Proc] 2024 Nov; Vol. 99 (11), pp. 1702-1709. Date of Electronic Publication: 2024 Aug 02.
DOI:	10.1016/j.mayocp.2024.04.010
Abstrakt:	Objective: To report the efficacy, safety, and feasibility of radiofrequency ablation (RFA) for T1 papillary thyroid carcinoma (PTC) in a large referral center in the United States. Patients and Methods: We conducted a retrospective study of 8 patients who underwent RFA for T1 PTC at Mayo Clinic in Rochester Minnesota, between July 1, 2020, and February 28, 2023. The RFA technique and the type of anesthesia are described. Thyroid function, changes in ablated zone, and adverse events were analyzed for up to 24 months after the procedure. Results: Of the 8 patients included in the study, 7 were female and 1 was male with a mean ± SD age of 53±16.4 years. Thyroid status was unaffected in 7 of the 8 patients. The median duration of RFA was 6 minutes (range, 2 to 14.5 minutes) with energy delivered at between 25 and 45 W. The mean ± SD volume of small PTCs was 0.3±0.2 mL, and the mean largest diameter was 9.5±3.3 mm (range, 6 to 15 mm). The mean ± SD ablated volume at 3 to 6 months was larger than the target lesion (0.8±0.7 mL), with a reduction in mean ± SD ablated volume of 0.4±0.4 mL at 7 to 12 months and 0.1±0.06 mL at 13 to 18 months. The ablated zone almost disappeared at 19 to 24 months (0.04±0.04 mL). There were no major adverse events during or after the RFA procedure. Conclusion: This is the first reported series of T1 PTC treated with RFA in the United States. Early postablation imaging revealed that the ablated region was larger than the target lesions, followed by a serial decrease in size. Therefore, RFA at centers with such expertise appears to be a safe and effective treatment for small PTCs. Further studies are needed to evaluate its long-term efficacy and the risk of recurrence. (Copyright © 2024 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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