Retro-age: A unique epigenetic biomarker of aging captured by DNA methylation states of retroelements.

Autor: Ndhlovu LC; Department of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York, New York City, USA., Bendall ML; Department of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York, New York City, USA., Dwaraka V; TruDiagnostic, Lexington, Kentucky, USA., Pang APS; Department of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York, New York City, USA., Dopkins N; Department of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York, New York City, USA., Carreras N; TruDiagnostic, Lexington, Kentucky, USA., Smith R; TruDiagnostic, Lexington, Kentucky, USA., Nixon DF; Department of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York, New York City, USA., Corley MJ; Department of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York, New York City, USA.
Jazyk: angličtina
Zdroj: Aging cell [Aging Cell] 2024 Oct; Vol. 23 (10), pp. e14288. Date of Electronic Publication: 2024 Aug 02.
DOI: 10.1111/acel.14288
Abstrakt: Reactivation of retroelements in the human genome has been linked to aging. However, whether the epigenetic state of specific retroelements can predict chronological age remains unknown. We provide evidence that locus-specific retroelement DNA methylation can be used to create retroelement-based epigenetic clocks that accurately measure chronological age in the immune system, across human tissues, and pan-mammalian species. We also developed a highly accurate retroelement epigenetic clock compatible with EPICv.2.0 data that was constructed from CpGs that did not overlap with existing first- and second-generation epigenetic clocks, suggesting a unique signal for epigenetic clocks not previously captured. We found retroelement-based epigenetic clocks were reversed during transient epigenetic reprogramming, accelerated in people living with HIV-1, and responsive to antiretroviral therapy. Our findings highlight the utility of retroelement-based biomarkers of aging and support a renewed emphasis on the role of retroelements in geroscience.
(© 2024 The Author(s). Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje