Luminous blue carbon quantum dots employing Anisomeles indica (catmint) induce apoptotic signaling pathway in triple negative breast cancer (TNBC) cells.

Autor: Kumar P; Food Chemistry and Molecular Cancer Biology, Department of Animal Health and Management, Alagappa University, Karaikudi, Tamil Nadu, India., Mahalakshmi M; Food Chemistry and Molecular Cancer Biology, Department of Animal Health and Management, Alagappa University, Karaikudi, Tamil Nadu, India., Anitha S; Food Chemistry and Molecular Cancer Biology, Department of Animal Health and Management, Alagappa University, Karaikudi, Tamil Nadu, India., Durgadevi S; Food Chemistry and Molecular Cancer Biology, Department of Animal Health and Management, Alagappa University, Karaikudi, Tamil Nadu, India., Govarthanan M; Department of Environmental Engineering, Kyungpook National University, Daegu, South Korea.
Jazyk: angličtina
Zdroj: Luminescence : the journal of biological and chemical luminescence [Luminescence] 2024 Aug; Vol. 39 (8), pp. e4848.
DOI: 10.1002/bio.4848
Abstrakt: Herein, luminous blue carbon quantum dots (CDs) employing Anisomeles indica (Catmint) were reported with imaging, self-targeting, and therapeutic effects on triple-negative breast cancer (TNBC, MDA-MB-231) cells. The salient features of CDs generated from catmint are as follows: i) optical studies confirm CDs with excitation-dependent emission; ii) high-throughput characterization authenticates the formation of CDs with near-spherical shape with diameter ranging between 5 and 15 nm; iii) CDs induce cytotoxicity (3.22 ± 0.64 μg/ml) in triple-negative breast cancer (TNBC, MDA-MB-231) cells; iv) fluorescence microscopy demonstrates that CDs promote apoptosis by increasing reactive oxygen species (ROS) and decreasing mitochondrial membrane potential; v) CDs significantly up-regulate pro-apoptotic gene expression levels such as caspases-8/9/3. Finally, our work demonstrates that catmint-derived CDs are prospective nanotheranostics that augment cancer targeting and imaging.
(© 2024 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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