The Role of Receptor Activator of Nuclear Factor-κB Ligand/Osteoprotegerin Ratio in Synovial Fluid as a Potential Marker for Periprosthetic Osteolysis Following Total Ankle Arthroplasty.

Autor:	Lee GW; Department of Orthopedic Surgery, Chonnam National University Hospital, Gwangju, Korea.; Department of Orthopedic Surgery, Chonnam National University Medical School, Gwangju, Korea., Song JE; Department of Orthopedic Surgery, Chonnam National University Hospital, Gwangju, Korea., Han JE; Department of Orthopedic Surgery, Chonnam National University Hospital, Gwangju, Korea., Kim NS; Department of Pharmacology, Chonnam National University Medical School, Gwangju, Korea., Lee KB; Department of Orthopedic Surgery, Chonnam National University Hospital, Gwangju, Korea.; Department of Orthopedic Surgery, Chonnam National University Medical School, Gwangju, Korea.
Jazyk:	angličtina
Zdroj:	Clinics in orthopedic surgery [Clin Orthop Surg] 2024 Aug; Vol. 16 (4), pp. 661-668. Date of Electronic Publication: 2024 Jun 07.
DOI:	10.4055/cios23411
Abstrakt:	Background: Periprosthetic osteolysis is a prevalent complication following total ankle arthroplasty (TAA), implicating various cytokines in osteoclastogenesis as pivotal in this process. This study aimed to evaluate the relationship between osteolysis and the concentrations of osteoclastogenesis-related cytokines in synovial fluid and investigate its clinical value following TAA. Methods: Synovial fluid samples from 23 ankles that underwent revision surgery for osteolysis following TAA were analyzed as the osteolysis group. As a control group, we included synovial fluid samples obtained from 23 ankles during primary TAA for osteoarthritis. The receptor activator of nuclear factor-κB ligand (RANKL)/osteoprotegerin (OPG) ratio in these samples was quantified using sandwich enzyme-linked immunosorbent assay techniques, and a bead-based multiplex immunoassay facilitated the detection of specific osteoclastogenesis-related cytokines. Results: RANKL levels averaged 487.9 pg/mL in 14 of 23 patients in the osteolysis group, with no detection in the control group's synovial fluid. Conversely, a significant reduction in OPG levels was observed in the osteolysis group ( p = 0.002), resulting in a markedly higher mean RANKL/OPG ratio (0.23) relative to controls ( p = 0.020). Moreover, the osteolysis group had increased concentrations of various osteoclastogenesis-related cytokines (tumor necrosis factor-α, interleukin [IL]-1β, IL-6, IL-8, IP-10, and monocyte chemotactic protein-1) in the synovial fluid relative to the control group. Conclusions: Our results demonstrated that periprosthetic osteolysis was associated with osteoclastogenesis activation through an elevated RANKL/OPG ratio following TAA. We assume that RANKL and other osteoclastogenesis-related cytokines in the synovial fluid have clinical value as a potential marker for the development and progression of osteolysis following TAA. Competing Interests: CONFLICT OF INTEREST: No potential conflict of interest relevant to this article was reported. (Copyright © 2024 by The Korean Orthopaedic Association.)
Databáze:	MEDLINE
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