Transcranial Focused Ultrasound Targeting the Amygdala May Increase Psychophysiological and Subjective Negative Emotional Reactivity in Healthy Older Adults.

Autor:	Hoang-Dang B; Department of Psychiatry and Behavioral Sciences, University of California, Los Angeles, Los Angeles, California., Halavi SE; Department of Psychiatry and Behavioral Sciences, University of California, Los Angeles, Los Angeles, California., Rotstein NM; Department of Psychiatry and Behavioral Sciences, University of California, Los Angeles, Los Angeles, California., Spivak NM; Department of Psychiatry and Behavioral Sciences, University of California, Los Angeles, Los Angeles, California.; Department of Neurosurgery, University of California, Los Angeles, Los Angeles, California.; UCLA David Geffen School of Medicine Medical Scientist Training Program, University of California, Los Angeles, Los Angeles, California., Dang NH; Department of Psychiatry and Behavioral Sciences, University of California, Los Angeles, Los Angeles, California.; Department of Radiology, University of Colorado School of Medicine, Aurora, Colorado., Cvijanovic L; Neuroscience Interdepartmental Program, University of California, Los Angeles, Los Angeles, California., Hiller SH; Department of Psychiatry and Behavioral Sciences, University of California, Los Angeles, Los Angeles, California., Vallejo-Martelo M; Department of Psychiatry and Behavioral Sciences, University of California, Los Angeles, Los Angeles, California.; Department of Neurosurgery, University of California, Los Angeles, Los Angeles, California.; Department of Bioengineering, University of California, Los Angeles, Los Angeles, California., Rosenberg BM; Department of Psychology, University of California, Los Angeles, Los Angeles, California., Swenson A; Neuroscience Interdepartmental Program, University of California, Los Angeles, Los Angeles, California., Becerra S; Department of Psychiatry and Behavioral Sciences, University of California, Los Angeles, Los Angeles, California., Sun M; Department of Psychology, University of California, Los Angeles, Los Angeles, California.; Department of Psychological and Brain Sciences, Dartmouth College, Hanover, New Hampshire., Revett ME; Department of Psychiatry and Behavioral Sciences, University of California, Los Angeles, Los Angeles, California., Kronemyer D; Department of Psychiatry and Behavioral Sciences, University of California, Los Angeles, Los Angeles, California., Berlow R; American Brain Stimulation Clinic, Del Mar, California., Craske MG; Department of Psychology, University of California, Los Angeles, Los Angeles, California., Suthana N; Department of Psychiatry and Behavioral Sciences, University of California, Los Angeles, Los Angeles, California.; Department of Neurosurgery, University of California, Los Angeles, Los Angeles, California.; Department of Bioengineering, University of California, Los Angeles, Los Angeles, California.; Department of Psychology, University of California, Los Angeles, Los Angeles, California., Monti MM; Department of Psychiatry and Behavioral Sciences, University of California, Los Angeles, Los Angeles, California.; Department of Neurosurgery, University of California, Los Angeles, Los Angeles, California.; Department of Psychology, University of California, Los Angeles, Los Angeles, California., Zbozinek TD; Department of Psychiatry and Behavioral Sciences, University of California, Los Angeles, Los Angeles, California.; Department of Psychology, University of California, Los Angeles, Los Angeles, California., Bookheimer SY; Department of Psychiatry and Behavioral Sciences, University of California, Los Angeles, Los Angeles, California., Kuhn TP; Department of Psychiatry and Behavioral Sciences, University of California, Los Angeles, Los Angeles, California.
Jazyk:	angličtina
Zdroj:	Biological psychiatry global open science [Biol Psychiatry Glob Open Sci] 2024 Jun 05; Vol. 4 (5), pp. 100342. Date of Electronic Publication: 2024 Jun 05 (Print Publication: 2024).
DOI:	10.1016/j.bpsgos.2024.100342
Abstrakt:	Background: The amygdala is highly implicated in an array of psychiatric disorders but is not accessible using currently available noninvasive neuromodulatory techniques. Low-intensity transcranial focused ultrasound (TFUS) is a neuromodulatory technique that has the capability of reaching subcortical regions noninvasively. Methods: We studied healthy older adult participants ( N  = 21, ages 48-79 years) who received TFUS targeting the right amygdala and left entorhinal cortex (active control region) using a 2-visit within-participant crossover design. Before and after TFUS, behavioral measures were collected via the State-Trait Anxiety Inventory and an emotional reactivity and regulation task utilizing neutral and negatively valenced images from the International Affective Picture System. Heart rate and self-reported emotional valence and arousal were measured during the emotional reactivity and regulation task to investigate subjective and physiological responses to the task. Results: Significant increases in both self-reported arousal in response to negative images and heart rate during emotional reactivity and regulation task intertrial intervals were observed when TFUS targeted the amygdala; these changes were not evident when the entorhinal cortex was targeted. No significant changes were found for state anxiety, self-reported valence to the negative images, cardiac response to the negative images, or emotion regulation. Conclusions: The results of this study provide preliminary evidence that a single session of TFUS targeting the amygdala may alter psychophysiological and subjective emotional responses, indicating some potential for future neuropsychiatric applications. However, more work on TFUS parameters and targeting optimization is necessary to determine how to elicit changes in a more clinically advantageous way.
Databáze:	MEDLINE
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