Therapeutic DBS for OCD Suppresses the Default Mode Network.

Autor:	Slepneva N; Weill Institute for Neurosciences, University of California, San Francisco.; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco., Basich-Pease G; Weill Institute for Neurosciences, University of California, San Francisco.; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco., Reid L; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco.; Department of Radiology and Biomedical Imaging, University of California, San Francisco., Frank AC; Department of Psychiatry and Behavioral Sciences, Keck School of Medicine of USC., Norbu T; Weill Institute for Neurosciences, University of California, San Francisco.; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco., Krystal AD; Weill Institute for Neurosciences, University of California, San Francisco.; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco., Sugrue LP; Weill Institute for Neurosciences, University of California, San Francisco.; Department of Radiology and Biomedical Imaging, University of California, San Francisco., Motzkin JC; Weill Institute for Neurosciences, University of California, San Francisco.; Departments of Neurology and Anesthesia and Perioperative Care, University of California, San Francisco., Larson PS; Department of Neurosurgery, University of Arizona., Starr PA; Weill Institute for Neurosciences, University of California, San Francisco.; Department of Neurological Surgery, University of California, San Francisco., Morrison MA; Weill Institute for Neurosciences, University of California, San Francisco.; Department of Radiology and Biomedical Imaging, University of California, San Francisco., Lee AM; Weill Institute for Neurosciences, University of California, San Francisco.; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2024 Jul 24. Date of Electronic Publication: 2024 Jul 24.
DOI:	10.1101/2024.07.21.601827
Abstrakt:	Background: Deep brain stimulation (DBS) of the anterior limb of the internal capsule (ALIC) is an emerging treatment for severe, refractory obsessive-compulsive disorder (OCD). The therapeutic effects of DBS are hypothesized to be mediated by direct modulation of a distributed cortico-striato-thalmo-cortical network underlying OCD symptoms. However, the exact underlying mechanism by which DBS exerts its therapeutic effects still remains unclear. Method: In five participants receiving DBS for severe, refractory OCD (3 responders, 2 non-responders), we conducted a DBS On/Off cycling paradigm during the acquisition of functional MRI to determine the network effects of stimulation across a variety of bipolar configurations. We also performed tractography using diffusion-weighted imaging (DWI) to relate the functional impact of DBS to the underlying structural connectivity between active stimulation contacts and functional brain networks. Results: We found that therapeutic DBS had a distributed effect, suppressing BOLD activity within regions such as the orbitofrontal cortex, dorsomedial prefrontal cortex, and subthalamic nuclei compared to non-therapeutic configurations. Many of the regions suppressed by therapeutic DBS were components of the default mode network (DMN). Moreover, the estimated stimulation field from the therapeutic configurations exhibited significant structural connectivity to core nodes of the DMN. Conclusions: Therapeutic DBS for OCD suppresses BOLD activity within a distributed set of regions within the DMN relative to non-therapeutic configurations. We propose that these effects may be mediated by interruption of communication through structural white matter connections surrounding the DBS active contacts.
Databáze:	MEDLINE
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